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Community-Based Pilot Study of Chlamydia trachomatis and Neisseria gonorrhoeae Urogenital Infections Among Young Adults in the North and the Central Coast of Portugal

2025-09-25Artigo científico Acesso aberto
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dc.contributor.authorRodrigues, Rafaela
dc.contributor.authorLoureiro, Sónia
dc.contributor.authorJoão, Inês
dc.contributor.authorJordão, Inês
dc.contributor.authorBorrego, Maria José
dc.contributor.authorCatalão, Carlos
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorSousa, Carlos
dc.contributor.authorVale, Nuno
dc.date.accessioned2026-02-06T13:40:33Z
dc.date.available2026-02-06T13:40:33Z
dc.date.issued2025-09-25
dc.description(This article belongs to the Section Epidemiology & Public Health)
dc.description.abstractBackground and Objectives: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are among the most common sexually transmitted infections (STIs), with the highest incidence in individuals aged up to 25 years. However, data from Portugal remain scarce. This cross-sectional pilot study aimed to assess the prevalence of urogenital CT and NG infections in young adults in Portugal and to identify the major CT genotypes circulating in this population. Materials and Methods: A total of 152 young adults aged 18-25 years were recruited over a six-month period from universities, a sports club, and a coworking space. Urine samples were tested using the Cobas 4800 CT/NG assay (Roche, Rotkreuz, Switzerland). CT-positive samples were further genotyped based on ompA gene diversity to identify major urogenital genotypes (D to K). All participants provided informed consent and completed a questionnaire on demographic characteristics and risk behaviors. Results: Of the 152 urine samples analyzed, five tested positive for CT, one for NG, and one sample showed co-infection with both pathogens. None of the participants with positive results reported symptoms. Genotyping of CT-positive samples identified ompA genotype E in three cases. Conclusions: Despite limitations such as small sample size and convenience sampling, this pilot study offers preliminary insights into the prevalence and genetic diversity of CT and NG infections among young adults in Portugal. The findings highlight the need for expanded screening programs, site-specific sample collection, and culture-based diagnostics to support evidence-based public health strategies targeting these infections.eng
dc.description.sponsorshipThis work was financed by FEDER—Fundo Europeu de Desenvolimento Regional through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia, in a framework of the projects in CINTESIS, R&D Unit (reference UIDB/4255/2020), and within the scope of the project RISE—LA/P/0053/2020. N.V. would also like to thank FCT and FEDER (European Union), award number IF/00092/2014/CP1255/CT0004, PRR-09/C06-834I07/2024.P11721, 2024.18026.PEX and the Chair in Onco-Innovation at the FMUP.
dc.identifier.citationMedicina (Kaunas). 2025 Sep 25;61(10):1749. doi: 10.3390/medicina61101749
dc.identifier.doi10.3390/medicina61101749
dc.identifier.eissn1648-9144
dc.identifier.issn1010-660X
dc.identifier.pmid41155735
dc.identifier.urihttp://hdl.handle.net/10400.18/10824
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationStudy of screening and genotyping of genital Chlamydia trachomatis in urine specimens from male and female clients in Portugal and its impact in cervical cancer and infertility
dc.relation.hasversionhttps://www.mdpi.com/1648-9144/61/10/1749
dc.relation.ispartofMedicina
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChlamydial Infections
dc.subjectDual-Screening
dc.subjectGonococcal Infections
dc.subjectompA-genotyping
dc.subjectSexually Transmitted Infections
dc.subjectInfecções Sexualmente Transmissíveis
dc.subjectPortugal
dc.titleCommunity-Based Pilot Study of Chlamydia trachomatis and Neisseria gonorrhoeae Urogenital Infections Among Young Adults in the North and the Central Coast of Portugaleng
dc.typejournal article
dcterms.referenceshttps://www.mdpi.com/1648-9144/61/10/1749#Appendix_A
dspace.entity.typePublication
oaire.awardTitleStudy of screening and genotyping of genital Chlamydia trachomatis in urine specimens from male and female clients in Portugal and its impact in cervical cancer and infertility
oaire.awardURIhttp://hdl.handle.net/10400.18/10823
oaire.citation.issue10
oaire.citation.startPage1749
oaire.citation.titleMedicina
oaire.citation.volume61
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
relation.isProjectOfPublication2793ea45-4fec-4053-ac37-d0482678076f
relation.isProjectOfPublication.latestForDiscovery2793ea45-4fec-4053-ac37-d0482678076f

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