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Chlamydia trachomatis outbreak: when the virulence-associated genome backbone imports a prevalence-associated major antigen signature

2019-09-19Conference object Restricted access
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dc.contributor.authorBorges, Vitor
dc.contributor.authorCordeiro, Dora
dc.contributor.authorSalas, Ana Isabel
dc.contributor.authorLodhia, Zohra
dc.contributor.authorCorreia, Cristina
dc.contributor.authorIsidro, Joana
dc.contributor.authorFernandes, Cândida
dc.contributor.authorRodrigues, Ana
dc.contributor.authorAzevedo, Jacinta
dc.contributor.authorAlves, João
dc.contributor.authorRôxo, João
dc.contributor.authorRocha, Miguel
dc.contributor.authorCorte-Real, Rita
dc.contributor.authorVieira, Luís
dc.contributor.authorBorrego, Maria José
dc.contributor.authorGomes, João Paulo
dc.date.accessioned2020-09-15T15:02:01Z
dc.date.available2020-09-15T15:02:01Z
dc.date.issued2019-09-19
dc.description.abstractChlamydia trachomatis is the most prevalent sexually transmitted bacterium worldwide and the causative agent of trachoma. Its strains are classified according to their ompA genotypes, which are strongly linked to differential tissue tropism and disease outcomes [ocular disease, urogenital disease and lymphogranuloma venereum (LGV)]. While the genome-based species phylogenetic tree presents four main clades correlating with tropism/prevalence, namely ocular, LGV, urogenital T1 (more prevalent genotypes) and urogenital T2 (less prevalent genotypes), inter-clade exchange of ompA is considered a rare phenomenon probably mediating marked tropism alterations. An LGV epidemic, associated with the clonal expansion of the L2b genotype, has emerged in the last few decades, raising concerns particularly due to its atypical clinical presentation (ulcerative proctitis) and circulation among men who have sex with men (MSM).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7195
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectChlamydia trachomatis;pt_PT
dc.subjectInter-clade Exchangept_PT
dc.subjectLymphogranuloma venereum (LGV)pt_PT
dc.subjectompApt_PT
dc.subjectOutbreakpt_PT
dc.subjectRecombinationpt_PT
dc.subjectInfecções Sexualmente Transmissíveispt_PT
dc.titleChlamydia trachomatis outbreak: when the virulence-associated genome backbone imports a prevalence-associated major antigen signaturept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceDubrovnik, Croatiapt_PT
oaire.citation.title12th International Meeting on Microbial Epidemiological Markers (IMMEM XII), “Moving towards genome-based pathogen surveillance – lessons learnt and challenges ahead”, 18-21 September 2019pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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