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Exposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event: results from a population-based study in Portugal

2021-03-20Journal article Restricted access
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dc.contributor.authorGaio, Vânia
dc.contributor.authorRoquette, Rita
dc.contributor.authorMonteiro, Alexandra
dc.contributor.authorFerreira, Joana
dc.contributor.authorRafael, Sandra
dc.contributor.authorDias, Carlos Matias
dc.contributor.authorNunes, Baltazar
dc.date.accessioned2022-02-03T16:17:02Z
dc.date.available2023-03-21T01:30:28Z
dc.date.issued2021-03-20
dc.description.abstractVariations in blood count parameters are potential mechanisms involved in the occurrence of cardiovascular events caused by particulate matter (PM) exposure. This study aims to estimate the effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event. We used data from 2211 participants of the 1st Portuguese Health Examination Survey (INSEF, 2015) with available information on blood count parameters and living within a 30-km radius of at least one air quality monitoring station with available PM10 measurements. Generalised linear models were used to assess both short (3 days) and long-term effects (1 year) of PM10 exposure on blood count parameters. Both short and long-term PM10 effects on blood count parameters were found, with males and females affected in a different way. In the short-term scenario, we found a 2.76% (95% CI: 0.65–4.87) increase in white blood cells among females per each 10μg/m3 PM10 increment. Additionally, there was a 2.96% (95% CI: 0.80–5.12) increase in red cell distribution width (RDW), per each 10μg/m3 PM10 increment, among males, when considering the long-term scenario. In conclusion, we detected some sex-differential associations regarding the short and long-term effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event, namely on the RDW parameter, that were never been described. It is uncertain whether changes in blood count parameters due to PM10 exposure constitute an adverse health outcome or it reflects only a normal immunity response. However, due to its potential to trigger cardiovascular events, it is essential to reduce PM10 levels exposure to protect the population’s cardiovascular health.pt_PT
dc.description.sponsorshipINSEF was developed as part of the Pre-defined project financed under the Public Health Initiatives Program. “Improvement of epidemiological health information to support public health decision and management in Portugal. Towards reduced inequalities, improved health and bilateral cooperation” with a 1.500.000€ Grant from Iceland, Liechtenstein and Norway from EEA Grants and the Portuguese Government. The present study was also funded by the Portuguese Foundation for Science and Technology (FCT) (PhD Scholarship Reference: SFRH/BD/129426/2017). J. Ferreira is funded by national funds (OE), through FCT – Fundação para a Ciência e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. Thanks are also due to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAir Qual Atmos Health. 2021 Mar 20;14(8):1189-1202. doi:10.1007/s11869-021-01007-9pt_PT
dc.identifier.doi10.1007/s11869-021-01007-9pt_PT
dc.identifier.issn1873-9318
dc.identifier.urihttp://hdl.handle.net/10400.18/7921
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationEffects of air pollution exposure on cardiovascular outcomes: Linkage between the first National Health Examination Survey and the Environmental data
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs11869-021-01007-9pt_PT
dc.subjectAmbient Particulate Matterpt_PT
dc.subjectHealth Examination Surveypt_PT
dc.subjectBlood Countspt_PT
dc.subjectParticulate Matterpt_PT
dc.subjectRDWpt_PT
dc.subjectRed Cell Distribution Widthpt_PT
dc.subjectLeucocytespt_PT
dc.subjectPlateletspt_PT
dc.subjectINSEFpt_PT
dc.subjectInquérito Nacional de Saúde com Exame Físicopt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectPortugalpt_PT
dc.subjectINSEF 2015pt_PT
dc.titleExposure to ambient particulate matter increases blood count parameters with potential to mediate a cardiovascular event: results from a population-based study in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEffects of air pollution exposure on cardiovascular outcomes: Linkage between the first National Health Examination Survey and the Environmental data
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F129426%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.endPage1202pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1189pt_PT
oaire.citation.titleAir Quality, Atmosphere and Healthpt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication5a8a3983-3f80-43a8-9729-25fbfa3ae156
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