Repository logo
 
Publication

Predominance of Genotype 5 Hepatitis Delta Virus Infection in a Portuguese Hepatology Unit

2024-08-21Journal article Open access
Simple item page
dc.contributor.authorCardoso, M.F.
dc.contributor.authorCoelho, H.
dc.contributor.authorBranco, J.C.
dc.contributor.authorBraganca, S.
dc.contributor.authorAlexandrino, G.
dc.contributor.authorCosta, M.N.
dc.contributor.authorCarvalho, R.
dc.contributor.authorPádua, E.
dc.contributor.authorMartins, A
dc.date.accessioned2025-03-05T10:41:41Z
dc.date.available2025-03-05T10:41:41Z
dc.date.issued2024-08-21
dc.descriptionThis article belongs to the Special Issue Viral Hepatitis: Prevention, Infection, and Treatment.
dc.description.abstractHepatitis delta virus (HDV) infection is the most severe form of viral hepatitis. Genotype 1 (HDV-1) is by far the most prevalent in Europe and globally, while HDV-5 predominates in Western Africa. Data about HDV seroprevalence in Portugal are scarce and genotyping studies have not been performed yet. We aimed to assess the seroprevalence and genotypes of HDV in a large cohort of HBsAg-positive patients followed in our Hepatology Unit between 2012 and 2022. The anti-HDV-positive patients were subjected to a cross-sectional analysis, including blood sample collection for HDV RNA testing and genotype determination. In the cohort of HBsAg-positive patients, 57.5% (480/835) were born in African countries and 665/835 (79.6%) had been screened for anti-HDV antibodies. The HDV seroprevalence obtained was 6.5% (43/665). Twenty-one patients (age 41.2 ± 9.9 years; 57.1% male) were included in further molecular analyses. HDV RNA was positive in 8/21 (38.0%) and classified as HDV-5 in 7 patients (6 from Guinea-Bissau and 1 from Cape Verde) and HDV-1 in 1 patient (from Ukraine). In the largest and most comprehensive study performed in Portugal regarding HDV epidemiology to date, seroprevalence and genotype distribution of HDV (with predominance of HDV-5) were strongly influenced by immigration, notably from African countries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLivers. 2024 Aug 21;4(3):388-397. doi: 10.3390/livers4030028
dc.identifier.doi10.3390/livers4030028
dc.identifier.issn2673-4389
dc.identifier.urihttp://hdl.handle.net/10400.18/10407
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/2673-4389/4/3/28
dc.relation.publisherversionhttps://www.mdpi.com/journal/liverspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHepatitis Delta Virus (HDV)pt_PT
dc.subjectHepatitis B Virus (HBV)pt_PT
dc.subjectGenotypingpt_PT
dc.subjectPortugalpt_PT
dc.titlePredominance of Genotype 5 Hepatitis Delta Virus Infection in a Portuguese Hepatology Unitpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage397pt_PT
oaire.citation.issue3
oaire.citation.startPage388pt_PT
oaire.citation.titleLivers
oaire.citation.volume4
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DDI - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais