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Systematic review on recent potential biomarkers of chronic obstructive pulmonary disease

2018-12-18Journal article Restricted access
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dc.contributor.authorAydindogan, Eda
dc.contributor.authorPenque, Deborah
dc.contributor.authorZoidakis, Jerome
dc.date.accessioned2019-03-01T16:48:16Z
dc.date.available2019-03-01T16:48:16Z
dc.date.issued2018-12-18
dc.description.abstractChronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and associated with decreased lung function and inflammation. The heterogeneity of COPD and its molecular and clinical features hinder efficient patient stratification and introduction of personalized therapeutic approaches. The available clinical tools do not efficiently predict the progression and exacerbations of the disease. Areas covered: An overview of the most recent studies on putative COPD protein biomarkers and the challenges for implementing their use in the clinical setting is presented. Expert commentary: Proteomics biomarker discovery in COPD has mostly focused on approaches evaluating specific proteins on a limited number of samples. The most promising protein candidates can be classified into five main biological categories: extracellular matrix (ECM) remodeling, inflammation/immune response, oxidative stress response, vascular tone regulation, and lipid metabolism. To efficiently stratify COPD patients and predict exacerbations, it will be necessary to implement biomarker panels to better represent the complex pathophysiology of this disease. The application of unbiased proteomics and bioinformatics followed by appropriate clinical validation studies will contribute to the achievement of this aim while increasing the number of validated biomarkers that can enter the qualification processes by the regulatory entities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationExpert Rev Mol Diagn. 2018 Dec 18:1-9. doi: 10.1080/14737159.2018.1559054. [Epub ahead of print]pt_PT
dc.identifier.doi10.1080/14737159.2018.1559054pt_PT
dc.identifier.issn1473-7159
dc.identifier.urihttp://hdl.handle.net/10400.18/6037
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/14737159.2018.1559054?journalCode=iero20pt_PT
dc.subjectChronic Obstructive Pulmonary Diseasept_PT
dc.subjectProtein Bbiomarkerspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectExacerbationspt_PT
dc.subjectMortalitypt_PT
dc.subjectProteomicspt_PT
dc.subjectGenómica Funcionalpt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.titleSystematic review on recent potential biomarkers of chronic obstructive pulmonary diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleExpert Review of Molecular Diagnosticspt_PT
rcaap.embargofctPolítica editorial da revistapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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