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Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles - A Systematic Review

2022-09-21Journal article Open access
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dc.contributor.authorRolo, Dora
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorVentura, Célia
dc.contributor.authorAlvito, Paula
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorMartins, Carla
dc.contributor.authorBettencourt, Ana
dc.contributor.authorJordan, Peter
dc.contributor.authorVital, Nádia
dc.contributor.authorPereira, Joana
dc.contributor.authorPinto, Fátima
dc.contributor.authorMatos, Paulo
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2022-11-02T14:33:39Z
dc.date.available2022-11-02T14:33:39Z
dc.date.issued2022-09-21
dc.descriptionThis article belongs to the Special Issue New Insights in Toxicity and Cytotoxicity of Nanomaterialspt_PT
dc.descriptionReviewpt_PT
dc.description.abstractTitanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA).pt_PT
dc.description.sponsorshipThis research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics (UIDP/00009/2020; UIDB/00009/2020), iMed.ULisboa (UIDB/04138/2020+UIDP/04138/2020), CESAM (UIDP/50017/ 2020+UIDB/50017/2020+LA/P/0094/2020), and BioISI (UID/MULTI/04046/2019). N.V. thanks the Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia, e Ensino Superior, for her PhD grant 2020.07168.BD. L.G. was supported by FCT Individual CEEC as a Principal Researcher Grant (CEECIND/03143/2017) and R.A. as an Assistant Researcher Grant (CEECIND/01570/2018)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNanomaterials (Basel). 2022 Sep 21;12(19):3275. doi: 10.3390/nano12193275.pt_PT
dc.identifier.doi10.3390/nano12193275pt_PT
dc.identifier.issn2079-4991
dc.identifier.urihttp://hdl.handle.net/10400.18/8296
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/12/19/3275pt_PT
dc.subjectTitanium Dioxidept_PT
dc.subjectNanoparticlespt_PT
dc.subjectIngested Nanomaterialspt_PT
dc.subjectAdverse Outcome Pathwayspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectVias de sinalização e patologias associadaspt_PT
dc.subjectToxicologiapt_PT
dc.titleAdverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles - A Systematic Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.citation.issue19pt_PT
oaire.citation.startPage3275pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVentura
person.familyNameSilva
person.familyNameLouro
person.givenNameCélia
person.givenNameMaria Joao
person.givenNameHenriqueta
person.identifier2056460
person.identifier157627
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id7710-643D-97A3
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0002-6060-0716
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id55944437600
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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