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Early-stage nanosafety assessment as a critical tool for innovative nanomaterials development

2021-05-05Conference object Restricted access
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dc.contributor.authorLouro, Henriqueta
dc.contributor.authorVentura, Célia
dc.contributor.authorRolo, Dora
dc.contributor.authorVital, Nádia
dc.contributor.authorPinto, Fátima
dc.contributor.authorSilva, Maria João
dc.date.accessioned2022-01-14T14:59:54Z
dc.date.available2022-01-14T14:59:54Z
dc.date.issued2021-05-05
dc.description.abstractThe perspectives of innovation through the use of nanomaterials (NMs) in key sectors such as agriculture, food industry, medicine, energy, environment, and electronics, has exponentially increased their development, production, and application. However, a major concern for public health is that some materials for long being considered safe for humans, e.g., titanium dioxide or cellulose fibers, can acquire different properties at the nanoscale that, despite being more attractive for industrial applications, may also elicit nano-bio interactions and toxic effects. Furthermore, their physicochemical properties can be influenced by the surrounding matrix or by physiological processes, such as digestion or inhalation, that modify their primary physicochemical properties. These secondary features may also influence the NMs toxicity and associated adverse health outcomes, such chronic inflammation and/or cancer. Therefore, the safety assessment of NMs must be conducted early in their development process and follow the nanotoxicology principles, in order to unveil the most relevant physicochemical characteristics that determine their potential adverse effects. In this work, the nanotoxicological investigation for the case studies of titanium dioxide NMs and nanocelluloses are presented. They illustrate the establishment of relationships between NMs characteristics and their toxicological properties and how they may direct the synthesis of innovative and safer NMs. If such tool is used at an early stage of NMs or product development, it moves industry towards a safe and sustainable by design (SSBD) approach that will enable safety to keep pace with innovation for the benefit of citizens. The Portuguese ISO/CEN Technical Commission for Nanotechnologies (CT194) is acknowledged for its role in bridging the gap between science and industry.pt_PT
dc.description.sponsorshipWork funded by FCT/MCTES through national funds (PIDDAC) PTDC/SAU-PUB/29481/2017, PTDC/SAU-PUB/32587/2017, and UIDB/00009/2020; UIDP/00009/2020). NV holds a FCT PhD Scholarship grant 2020.07168.BD.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7852
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.subjectNanomaterialspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectSafety Assessmentpt_PT
dc.subjectStandardizationpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleEarly-stage nanosafety assessment as a critical tool for innovative nanomaterials developmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.titleEuroNanoForum 2021 conference, European Commission and EU Presidency, 5-6 May 2021pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLouro
person.familyNameVentura
person.familyNameRolo
person.familyNameVital
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameCélia
person.givenNameDora
person.givenNameNádia
person.givenNameMaria Joao
person.identifier157627
person.identifier2056460
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id6116-89BA-C617
person.identifier.ciencia-id7E16-CFCA-B797
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-0637-2222
person.identifier.orcid0000-0003-4327-2279
person.identifier.orcid0000-0002-3391-0268
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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