Repository logo
 
Publication

How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

2023-04Journal article Open access
Simple item page
dc.contributor.authorSantonen, Tiina
dc.contributor.authorMahiout, Selma
dc.contributor.authorAlvito, Paula
dc.contributor.authorApel, Petra
dc.contributor.authorBessems, Jos
dc.contributor.authorBil, Wieneke
dc.contributor.authorBorges, Teresa
dc.contributor.authorBose-O'Reilly, Stephan
dc.contributor.authorBuekers, Jurgen
dc.contributor.authorCañas Portilla, Ana Isabel
dc.contributor.authorCalvo, Argelia Castaño
dc.contributor.authorde Alba González, Mercedes
dc.contributor.authorDomínguez-Morueco, Noelia
dc.contributor.authorLópez, Marta Esteban
dc.contributor.authorFalnoga, Ingrid
dc.contributor.authorGerofke, Antje
dc.contributor.authorCaballero, María del Carmen González
dc.contributor.authorHorvat, Milena
dc.contributor.authorHuuskonen, Pasi
dc.contributor.authorKadikis, Normunds
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorLange, Rosa
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMartins, Carla
dc.contributor.authorMeslin, Matthieu
dc.contributor.authorNiemann, Lars
dc.contributor.authorDíaz, Susana Pedraza
dc.contributor.authorPlichta, Veronika
dc.contributor.authorPorras, Simo P.
dc.contributor.authorRousselle, Christophe
dc.contributor.authorScholten, Bernice
dc.contributor.authorSilva, Maria João
dc.contributor.authorŠlejkovec, Zdenka
dc.contributor.authorTratnik, Janja Snoj
dc.contributor.authorJoksić, Agnes Šömen
dc.contributor.authorTarazona, Jose V.
dc.contributor.authorUhl, Maria
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorViegas, Susana
dc.contributor.authorVinggaard, Anne Marie
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorSchoeters, Greet
dc.date.accessioned2023-10-11T13:01:42Z
dc.date.available2023-10-11T13:01:42Z
dc.date.issued2023-04
dc.description.abstractThe need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/polyfluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.pt_PT
dc.description.sponsorshipThis project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors’ organisations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2023 Apr:249:114139. doi: 10.1016/j.ijheh.2023.114139. Epub 2023 Mar 2.pt_PT
dc.identifier.doi10.1016/j.ijheh.2023.114139pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/8692
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463923000305?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectChemicalspt_PT
dc.subjectEnvironmental Burden of Diseasept_PT
dc.subjectExposure Biomarkerspt_PT
dc.subjectHBM4EUpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectAvaliação do Riscopt_PT
dc.titleHow to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EUpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage114139pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume249pt_PT
oaire.fundingStreamH2020
person.familyNameAlvito
person.familyNameLouro
person.familyNameSilva
person.givenNamePaula
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier125777
person.identifier157627
person.identifier.ciencia-id3B14-020B-5FB1
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-8396-1357
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.ridB-6977-2014
person.identifier.scopus-author-id8590147800
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com a política editorial da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication57d170c1-81ad-4982-9f81-29f365873c0a
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Santonen 2023 HBM methodological aspects.pdf
Size:
1.12 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DGH - Artigos em revistas internacionais
DAN - Artigos em revistas internacionais