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Proteomics in Detection and Monitoring Chronic Lung Diseases: The Human Nasal Epithelium as a Molecular Model

2012-02-22Journal article Open access
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dc.contributor.authorSimões, Tânia
dc.contributor.authorCharro, Nuno
dc.contributor.authorAlexandre, Bruno
dc.contributor.authorPenque, Deborah
dc.date.accessioned2012-10-24T14:09:57Z
dc.date.available2012-10-24T14:09:57Z
dc.date.issued2012-02-22
dc.description.abstractAsthma and chronic obstructive pulmonary disease (COPD) are major causes of mortality and morbidity worldwide. The current state-of-art diagnosis and management schemes are suboptimal for both diseases as the incidence of asthma has risen by 250% over the last two decades and COPD is estimated to become the third leading cause of death worldwide within the next decade. Additionally, these diseases represent a very important threat to global economies in direct and indirect medical costs and lost working days [1,2]. Asthma is a chronic inflammatory disorder of the airways associated with airway hyperresponsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing. These episodes are usually associated with widespread, but variable, airflow obstruction within the lung [1]. Chronic airflow obstruction is also characteristic of COPD but, in contrast to asthma, is not fully reversible, even under the action of bronchodilators, and is usually progressive. A combination of small airway disease -obstructive bronchiolitis - and parenchymal destruction - emphysema, leads to COPD clinical manifestation [2]. A number of factors influence a person’s risk of developing these lung diseases, which include host factors, primarily genetic, and environmental factors, such as allergens and tobacco smoke in asthma and COPD, respectivelypor
dc.identifier.citationJ Aller Ther 2012, S7. doi:10.4172/2155-6121.S7-004por
dc.identifier.issn2155-6121
dc.identifier.otherESSN: 2155-6121
dc.identifier.urihttp://hdl.handle.net/10400.18/1021
dc.language.isoengpor
dc.publisherOMICS Publishing Grouppor
dc.relation.publisherversionhttp://www.omicsonline.org/2155-6121/pdfdownload.php?download=2155-6121-S7-004.pdf&&aid=4925por
dc.subjectNasal Epitheliumpor
dc.subjectGenómica Funcional e Estruturalpor
dc.subjectProteomicspor
dc.subjectBiomarkerspor
dc.titleProteomics in Detection and Monitoring Chronic Lung Diseases: The Human Nasal Epithelium as a Molecular Modelpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Allergy & Therapypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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