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Publicação
Alternative mechanisms of mRNA translationiInitiation in cellular stress response and cancer
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Orientador(es)
Resumo(s)
Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in overall protein synthesis accompanied by induction of alternative mechanisms of mRNA translation initiation. Here, we present well-studied and recent examples of such stress responses and the alternative translation initiation mechanisms they induce, and discuss the consequences of such regulation for cell homeostasis and oncogenic transformation.
Descrição
Palavras-chave
Alternative Translation Initiation Cancer Cellular Stress IRES Non-AUG mRNA Translation. Doenças Genéticas Genómica Funcional e Estrutural
Contexto Educativo
Citação
Adv Exp Med Biol. 2019;1157:117-132. doi: 10.1007/978-3-030-19966-1_6
Editora
Springer Verlag