Regulation of the Alternative Splicing of Tumor-Related RAC1b by Signal Transduction Pathways

Gonçalves, Vânia; Matos, Paulo; Pereira, Joana; Henriques, Andreia; Jordan, Peter

http://hdl.handle.net/10400.18/5793

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Distinct genetic subtypes have been described in colon cancer, one of which involves overexpression of RAC1b, a variant generated by alternative splicing. Aberrant splicing is known to occur in cancer and can be caused by mutation in a gene or splicing factor but also represents a dynamic response to oncogene-induced cellular signaling and in this case it may be pharmacologically targeted. Here we explore how signaling pathways are involved in the deregulation of alternative RAC1b splicing in colorectal tumor cells.