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Assessment of occupational exposure to hexavalent chromium – recommendations from HBM4EU chromate study

2022-02-06Conference object Restricted access
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dc.contributor.authorSantonen, Tiina
dc.contributor.authorBocca, Beatrice
dc.contributor.authorBousoumah, Radia
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGalea, Karen S.
dc.contributor.authorGodderis, Lode
dc.contributor.authorGöen, Thomas
dc.contributor.authorHardy, Emilie
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorJanasik, Beata
dc.contributor.authorJones, Kate
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLeso, Veruscka
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMajery, Nicole
dc.contributor.authorNdaw, Sophie
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorPorras, Simo P.
dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorSepai, Ovnair
dc.contributor.authorSilva, Maria João
dc.contributor.authorvan Nieuwenhuyse, An
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.date.accessioned2023-10-10T15:04:51Z
dc.date.available2023-10-10T15:04:51Z
dc.date.issued2022-02-06
dc.descriptionThe Study Group - Portugal: Susana Viegas, Carina Ladeira, Edna Ribeiro, Ana Sofia Simões Zeferino, Adriano Pereira, ESTeSL Maria João Silva, Henriqueta Louro, Célia Ventura, Ana Tavares, Bruno Gomes, Catarina Afonso, Hermínia Pinhal, Ana Nogueira, Sílvia Reis Santos, Rodrigo Moreira, INSApt_PT
dc.description.abstractIntroduction: Hexavalent chromium (Cr(VI)) is an important occupational carcinogen. In addition to air monitoring biomonitoring is commonly applied to monitor exposure to Cr(VI). Within the EU biomonitoring initiative, HBM4EU, we explored the applicability of different biomonitoring methods in the assessment of occupational exposure to Cr(VI) in welding and surface treatment activities. Materials and Methods: A multi-center cross-sectional study was performed in Belgium, Finland, France, Italy, Poland, Portugal, the Netherlands, Luxembourg and United Kingdom. Harmonized procedures were used to collect biological and industrial hygiene samples. Contextual information was collected using questionnaires. Altogether 602 exposed workers and controls were included in the study. Exposure biomarkers studied included urinary, red blood cell (RBC) and plasma Cr, and exhaled breath condensate (EBC) Cr(VI)/Cr(III). In addition, number of effect biomarkers were studied. Results: All exposure markers showed highest exposure levels among chrome plating workers. U-Cr showed a good correlation with air Cr(VI) in bath platers and welders. Observed low correlations between different exposure biomarkers suggest that these approaches are not interchangeable but rather complementary. Conclusions: U-Cr showed its value as the first approach for the assessment of internal exposure to Cr(VI). We recommend pre- and post-shift samples for low exposure levels. RBC/P-Cr and EBC-Cr(VI)/Cr(III) provide additional information when more specific information on exposure is needed. The current exposure levels require analytical methods with high sensitivity.pt_PT
dc.description.sponsorshipHORIZON 2020 Programme, Contract No. 733032 HBM4EUpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8690
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectEnvironmental Healthpt_PT
dc.subjectChromiumpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleAssessment of occupational exposure to hexavalent chromium – recommendations from HBM4EU chromate studypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.conferencePlaceMelbourne, Rome (online)pt_PT
oaire.citation.title33rd International Congress on Occupational Health (ICOH2022), 6-10 february 2022pt_PT
oaire.fundingStreamH2020
person.familyNameLouro
person.familyNameSilva
person.givenNameHenriqueta
person.givenNameMaria Joao
person.identifier157627
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.ciencia-id7710-643D-97A3
person.identifier.orcid0000-0001-9744-7332
person.identifier.orcid0000-0002-6060-0716
person.identifier.scopus-author-id6507971479
person.identifier.scopus-author-id55944437600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2361a951-8b9a-4b90-92d6-f6384003a242
relation.isAuthorOfPublicationa7763685-7c34-468d-b958-9dd0aca66db4
relation.isAuthorOfPublication.latestForDiscovery2361a951-8b9a-4b90-92d6-f6384003a242
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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