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Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development

2014-06Artigo científico Acesso aberto
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dc.contributor.authorBrehony, Carina
dc.contributor.authorTrotter, Caroline L.
dc.contributor.authorRamsay, Mary E.
dc.contributor.authorJolley, Keith A.
dc.contributor.authorvan der Ende, Arie
dc.contributor.authorCarion, Françoise
dc.contributor.authorBerthelsen, Lene
dc.contributor.authorHoffmann, Steen
dc.contributor.authorHarðardóttir, Hjördís
dc.contributor.authorVazquez, Julio A.
dc.contributor.authorMurphy, Karen
dc.contributor.authorToropainen, Maija
dc.contributor.authorCaniça, Manuela
dc.contributor.authorFerreira, Eugenia
dc.contributor.authorDiggle, Mathew
dc.contributor.authorEdwards, Giles F
dc.contributor.authorTaha, Muhamed-Kheir
dc.contributor.authorStefanelli, Paola
dc.contributor.authorKriz, Paula
dc.contributor.authorGray, Steve J.
dc.contributor.authorFox, Andrew J.
dc.contributor.authorJacobsson, Susanne
dc.contributor.authorClaus, Heike
dc.contributor.authorVogel, Ulrich
dc.contributor.authorTzanakaki, Georgina
dc.contributor.authorHeuberger, Sigrid
dc.contributor.authorCaugant, Dominique A.
dc.contributor.authorFrosch, Matthias
dc.contributor.authorMaiden, Martin C. J.
dc.date.accessioned2015-02-25T16:52:28Z
dc.date.available2015-02-25T16:52:28Z
dc.date.issued2014-06
dc.description.abstractNew vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and ≥25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups.por
dc.identifier.citationClin Vaccine Immunol. 2014 Jun;21(6):847-53. doi: 10.1128/CVI.00133-14. Epub 2014 Apr 2por
dc.identifier.doi10.1128/CVI.00133-14
dc.identifier.issn1556-6811
dc.identifier.urihttp://hdl.handle.net/10400.18/2954
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Society for Microbiologypor
dc.relation.publisherversionhttp://cvi.asm.org/content/21/6/847.longpor
dc.subjectResistência aos Antibióticospor
dc.subjectNeisseria Meningitidispor
dc.subjectVaccine Developmentpor
dc.titleImplications of differential age distribution of disease-associated meningococcal lineages for vaccine developmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage853por
oaire.citation.startPage847por
oaire.citation.titleClinical and Vaccine Immunologypor
oaire.citation.volume21(6)por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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