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Individual risk factors associated with SARS-CoV-2 infection during Alpha variant in high-income countries: a systematic review and meta-analysis

2024-07-30Journal article Open access
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dc.contributor.authorMoniz, Marta
dc.contributor.authorPereira, Sofia
dc.contributor.authorSoares, Patricia
dc.contributor.authorAguiar, Pedro
dc.contributor.authorDonato, Helena
dc.contributor.authorLeite, Andreia
dc.date.accessioned2025-04-04T13:14:08Z
dc.date.available2025-04-04T13:14:08Z
dc.date.issued2024-07-30
dc.description.abstractObjectives: This study aimed to systematically appraise risk factors associated with SARS-CoV-2 infection in high-income countries during the period of predominance of the Alpha variant (January 2020 to April 2021). Methods: Four electronic databases were used to search observational studies. Literature search, study screening, data extraction and quality assessment were conducted by two authors independently. Meta-analyses were conducted for each risk factor, when appropriate. Results: From 12,094 studies, 27 were included. The larger sample size was 17,288,532 participants, more women were included, and the age range was 18-117 years old. Meta-analyses identified men [Odds Ratio (OR): 1.23, 95% Confidence Interval (CI): 1.97-1.42], non-white ethnicity (OR: 1.63, 95% CI: 1.39-1.91), household number (OR: 1.08, 95% CI: 1.06-1.10), diabetes (OR: 1.22, 95% CI: 1.08-1.37), cancer (OR: 0.82, 95% CI: 0.68-0.98), cardiovascular diseases (OR: 0.92, 95% CI: 0.84-1.00), asthma (OR: 0.83, 95% CI: 0.75-0.92) and ischemic heart disease (OR: 0.82, 95% CI: 0.74-0.91) as associated with SARS-CoV-2 infection. Conclusion: This study indicated several risk factors for SARS-CoV-2 infection. Due to the heterogeneity of the studies included, more studies are needed to understand the factors that increase the risk for SARS-CoV-2 infection.pt_PT
dc.description.sponsorshipThis work was funded by the Foundation for Science and Technology (FCT) through a PhD research scholarship (2020.09525.BD) granted under the Call DOCTORATES 4 COVID-19; and FCT (reference: CEECINST/00049/2021/CP2817/CT0001 and DOI: 10.54499/CEECINST/00049/2021/CP2817/CT0001). This study is sponsored by Pfizer (grant code #68639655; URL: https://www.pfizer.pt/).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Public Health. 2024 Jul 30:12:1367480. doi: 10.3389/fpubh.2024.1367480. eCollection 2024
dc.identifier.doi10.3389/fpubh.2024.1367480pt_PT
dc.identifier.eissn2296-2565
dc.identifier.urihttp://hdl.handle.net/10400.18/10483
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media
dc.relationCovid-19 – Controlo da Covid-19 em Portugal numa perspetiva espácio-temporal: determinantes, tendências e previsões da incidência em unidades geográficas. Contributo para otimização de políticas
dc.relation.hasversionhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1367480/full
dc.relation.publisherversionhttps://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1367480/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2
dc.subjectInfectious Disease
dc.subjectMeta-analysis
dc.subjectRisk-factors
dc.subjectSystematic Review
dc.subjectMeta-análisept_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleIndividual risk factors associated with SARS-CoV-2 infection during Alpha variant in high-income countries: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCovid-19 – Controlo da Covid-19 em Portugal numa perspetiva espácio-temporal: determinantes, tendências e previsões da incidência em unidades geográficas. Contributo para otimização de políticas
oaire.awardURIhttp://hdl.handle.net/10400.18/10481
oaire.citation.startPage1367480
oaire.citation.titleFrontiers in Public Health
oaire.citation.volume12pt_PT
oaire.fundingStreamOE
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSoares
person.familyNameLeite
person.givenNamePatricia
person.givenNameAndreia
person.identifier1050496
person.identifier1052436
person.identifier.ciencia-id0415-632D-8609
person.identifier.ciencia-id2F10-F9A9-E8A7
person.identifier.orcid0000-0001-5033-9115
person.identifier.orcid0000-0003-0843-0630
person.identifier.scopus-author-id52063758300
person.identifier.scopus-author-id57109931300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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