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Is serotonin receptor HTR1B implicated in mesial temporal lobe epilepsy development?

2013-09-22Conference object Restricted access
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dc.contributor.authorLeal, B.
dc.contributor.authorBarreira, A.
dc.contributor.authorChaves, J.
dc.contributor.authorCarvalho, C.
dc.contributor.authorBettencourt, A.
dc.contributor.authorMartins da Silva, A.
dc.contributor.authorCosta, P.P.
dc.contributor.authorMartins da Silva, B.
dc.date.accessioned2014-04-03T10:35:05Z
dc.date.available2014-04-03T10:35:05Z
dc.date.issued2013-09-22
dc.description.abstractBackground: Evidences from animal models have demonstrated that depletion of brain serotonin (5-HT), a neurotransmitter with a pivotal role in neurodevelopment and brain plasticity, lowers the threshold to induced seizures. It was also demonstrated that anti-epileptic drugs increase endogenous 5-HT concentrations and that 5HT-1B receptors could have an anticonvulsant role. Association studies have demonstrated that a polymorphism (rs6296) in 5HTR-1B gene may be a susceptibility factor for with temporal lobe epilepsy (TLE) development. The rs6296 G allele has been associated with decreased receptor activity. Our aim was to analyse the association between rs6296 and the development and clinical features of Mesial Temporal Lobe Epilepsy (MTLE) in a Portuguese population. Material and methods: A cohort of 121 MTLE patients (67 F, 54 M, mean age = 44 ± 11 years, age of onset = 13 ± 9 years) was compared with a cohort of 192 healthy individuals (HI). All patients had Hippocampal Sclerosis (MTLE–HS). Genotyping was performed by TaqMan real time PCR methodology. Results: rs6296 G allele was overrepresented in MTLE patients compared to controls (80.2% in MTLE vs 72.1% in HI, p = 0.029 OR = 1.561 (1.060–2.298)). We constituted 2 MTLE–HS sub-groups, according to febrile seizure antecedents and no differences in rs6596 allelic or genotypic frequencies were found. Conclusion: The rs6296 G allele may be a susceptibility factor to MTLE–HS development. Since these receptors have an anticonvulsant role, a reduction in their activity could lower the threshold for seizure development.por
dc.description.sponsorshipSupported by a BICE Tecnifar Grant 2012por
dc.identifier.citationJ Neurol Sci. 2013;133(S1):e41por
dc.identifier.issn0022-510X
dc.identifier.urihttp://hdl.handle.net/10400.18/2216
dc.language.isoengpor
dc.peerreviewednopor
dc.publisherElsevier/ World Federation of Neurologypor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0022510X13004607
dc.subjectEpilepsypor
dc.subjectMTLEpor
dc.subjectSerotoninpor
dc.subjectHTR1Bpor
dc.subjectGenetic Associationpor
dc.subjectComplex Disease Geneticspor
dc.subjectDeterminantes da Saúde e da Doençapor
dc.subjectDoenças Genéticaspor
dc.titleIs serotonin receptor HTR1B implicated in mesial temporal lobe epilepsy development?por
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceVienna, Austriapor
oaire.citation.endPagee41por
oaire.citation.startPagee41por
oaire.citation.titleXXI World Congress of Neurology, 21-26 September 2013por
oaire.citation.volume333(S1)por
rcaap.rightsembargoedAccesspor
rcaap.typeconferenceObjectpor

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