Logo do repositório
 
Publicação

Urinary multi-mycotoxin exposure in the Portuguese population and associated sociodemographic determinants

2026-10-31Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
dc.contributor.authorMaris, Elias
dc.contributor.authorNamorado, Sónia
dc.contributor.authorChen, An
dc.contributor.authorPero-Gascon, Roger
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorSilva, Maria João
dc.contributor.authorAlvito, Paula
dc.date.accessioned2026-09-29T10:59:22Z
dc.date.available2026-09-29T10:59:22Z
dc.date.issued2026-10-31
dc.description.abstractEuropean human biomonitoring (HBM) studies have increasingly adopted multi-mycotoxin approaches to capture complex exposure scenarios encountered in real-life diets. This nation-wide study provides the characterization, for the first time, of the mycotoxin profile of 295 urine samples collected from the Portuguese population in the continent and islands (archipelagos of Madeira and Azores), using an optimized and validated LC-MS/MS method for the characterization of 39 mycotoxins/metabolites. Nearly all study participants (99.3%) were exposed to at least one mycotoxin, with around half (54.2%) being co-exposed to only 2 detectable mycotoxins. Free-deoxynivalenol (free-DON, 84.7%) and tenuazonic acid (TeA, 95.6%) were the most prevalent mycotoxins. Citrinin (CIT, 11.5%), α-zearalenone (α-ZEL, 10.5%) and ochratoxin A (OTA, 9.5%) showed detection rates near 10%. Median concentrations (P50) for the two predominant mycotoxins were 0.79 μg/L (0.72 μg/g creatinine) for free-DON and 2.45 μg/L (2.08 μg/g creatinine) for TeA, with maximum values of 11.77 μg/L (10.06 μg/g creatinine) and 90.91 μg/L (114.15 μg/g creatinine), respectively. Sociodemographic patterns showed lower exposure in the Centre region and higher free-DON exposure in southern Portugal and the archipelagos. TeA exposure differed significantly by region and was lowest in the Lisbon Metropolitan Area and Algarve compared to the Center reference region. Low educational levels and spring sampling correlated with higher exposure for both toxins, but only education levels showed statistical significance in the linear regression analyses. For both TeA and free-DON, no differences in exposure were observed by sex, occupational status, or degree of urbanization. Overall, these findings underscore the importance of continuous surveillance, particularly under the current climate change scenario, and highlight the relevance of integrating human biomonitoring into national food safety and public health strategies.eng
dc.description.abstractHighlights: -First nation-wide study on urinary multi-mycotoxin exposure in Portugal. -Optimized and validated LC-MS/MS method for 39 mycotoxins/metabolites. -Free-deoxynivalenol (DON, 84.7%) and tenuazonic acid (TeA, 95.6%) were most prevalent. -Free-DON and TeA exposure significantly varied depending on the geographic region. -Mycotoxin exposure varied significantly with sampling season and education level.por
dc.description.sponsorshipThe INSEF-ExpoQuim study was supported under the HBM4EU project that was co-funded by the European Union's research and innovation programme Horizon 2020 under grant agreement No. 733032 and by the participating countries through the participating organizations. The present study was supported by INSA, Ghent University and by national funds through FCT – Fundação para a Ciência e a Tecnologia, I.P., under the projects CESAM - Centro de Estudos do Ambiente e do Mar, references UID/50017/2025 (doi.org/10.54499/UID/50017/2025) and LA/P/0094/2020 (doi.org/10.54499/LA/P/0094/2020), and CHRC – Comprehensive Health Research Center, reference UID/06291/2025 (https://doi.org/10.54499/UID/06291/2025). Elias Maris is supported by an iBOF project from Flanders (grant number 01IB1320). An Chen is supported by an FWO (Research Foundation - Flanders) PhD Fellowship fundamental research (11A0725N). Roger Pero-Gascon is supported by an FWO Junior postdoctoral fellowship (12D4423N). Marthe De Boevre is supported by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No 946192, HUMYCO).
dc.identifier.citationFood Res Int. 2026 Oct 31;242(Pt 2):119820. doi: 10.1016/j.foodres.2026.119820. Epub 2026 Jun 23.
dc.identifier.doi10.1016/j.foodres.2026.119820
dc.identifier.eissn1873-7145
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10400.18/11349
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation733032
dc.relationUID/50017/2025
dc.relationLA/P/0094/2020
dc.relationUID/06291/2025
dc.relation01IB1320
dc.relation946192
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0963996926015048
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMycotoxins
dc.subjectHuman Biomonitoring
dc.subjectChemical Exposure
dc.subjectCo-Exposure
dc.subjectSociodemographic characteristics
dc.subjectFree-deoxynivalenol
dc.subjectTenuazonic Acid
dc.subjectUrine
dc.subjectExposome
dc.subjectPortugal
dc.subjectSegurança Alimentar
dc.subjectDeterminantes da Saúde e da Doença
dc.subjectToxicologia
dc.titleUrinary multi-mycotoxin exposure in the Portuguese population and associated sociodemographic determinantseng
dc.typejournal article
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0963996926015048-mmc1.docx
dspace.entity.typePublication
oaire.citation.issuePt 2
oaire.citation.startPage119820
oaire.citation.titleFood Research International
oaire.citation.volume242
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNamorado
person.familyNameSilva
person.familyNameAlvito
person.givenNameSónia
person.givenNameMaria João
person.givenNamePaula
person.identifier125777
person.identifier.ciencia-id3B14-020B-5FB1
person.identifier.orcid0000-0002-7500-8811
person.identifier.orcid0000-0001-8821-0747
person.identifier.orcid0000-0001-8396-1357
person.identifier.ridD-7168-2015
person.identifier.ridB-6977-2014
person.identifier.scopus-author-id14047182500
person.identifier.scopus-author-id8590147800
relation.isAuthorOfPublication4ed6a689-2426-46ea-90e6-1950652a288b
relation.isAuthorOfPublicationb2a2c2f7-2740-4657-8e50-7ff7fb468a96
relation.isAuthorOfPublication57d170c1-81ad-4982-9f81-29f365873c0a
relation.isAuthorOfPublication.latestForDiscovery4ed6a689-2426-46ea-90e6-1950652a288b

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Urinary multi-mycotoxin exposure in the Portuguese population and associated sociodemographic determinants.pdf
Tamanho:
1.77 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

DEP - Artigos em revistas internacionais
DAN - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais