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A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

2023-01-16Journal article Open access
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dc.contributor.authorMarx-Stoelting, P.
dc.contributor.authorRivière, G.
dc.contributor.authorLuijten, M.
dc.contributor.authorAiello-Holden, K.
dc.contributor.authorBandow, N.
dc.contributor.authorBaken, K.
dc.contributor.authorCañas, A.
dc.contributor.authorCastano, A.
dc.contributor.authorDenys, S.
dc.contributor.authorFillol, C.
dc.contributor.authorHerzler, M.
dc.contributor.authorIavicoli, I.
dc.contributor.authorKarakitsios, S.
dc.contributor.authorKlanova, J.
dc.contributor.authorKolossa-Gehring, M.
dc.contributor.authorKoutsodimou, A.
dc.contributor.authorLobo Vicente, J.
dc.contributor.authorLynch, I.
dc.contributor.authorNamorado, S.
dc.contributor.authorNorager, S.
dc.contributor.authorPittman, A.
dc.contributor.authorRotter, S.
dc.contributor.authorSarigiannis, D.
dc.contributor.authorSilva, M. J.
dc.contributor.authorTheunis, J.
dc.contributor.authorTralau, T.
dc.contributor.authorUhl, M.
dc.contributor.authorVan Klaveren, J.
dc.contributor.authorWendt-Rasch, L.
dc.contributor.authorWesterholm, E.
dc.contributor.authorRousselle, C.
dc.contributor.authorSanders, P.
dc.date.accessioned2023-10-06T09:41:18Z
dc.date.available2023-10-06T09:41:18Z
dc.date.issued2023-01-16
dc.descriptionLetter to the Editorpt_PT
dc.description.abstractCurrent approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical risk assessment and explorations of how to translate these concepts into pragmatic approaches. As a result, next-generation risk assessment (NGRA) is generally seen as the way forward. However, incorporating new scientific insights and innovative approaches into hazard and exposure assessments in such a way that regulatory needs are adequately met has appeared to be challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) has been designed to address various challenges associated with innovating chemical risk assessment. Its overall goal is to consolidate and strengthen the European research and innovation capacity for chemical risk assessment to protect human health and the environment. With around 200 participating organisations from all over Europe, including three European agencies, and a total budget of over 400 million euro, PARC is one of the largest projects of its kind. It has a duration of seven years and is coordinated by ANSES, the French Agency for Food, Environmental and Occupational Health & Safety.pt_PT
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL. The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101057014. Co-funding for the UK contribution via Innovate UK project ID 1752317 as part of the Horizon Europe Guarantee fund.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArch Toxicol. 2023 Mar;97(3):893-908. doi: 10.1007/s00204-022-03435-7. Epub 2023 Jan 16.pt_PT
dc.identifier.doi10.1007/s00204-022-03435-7pt_PT
dc.identifier.issn0340-5761
dc.identifier.urihttp://hdl.handle.net/10400.18/8657
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation101057014pt_PT
dc.relation1752317pt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00204-022-03435-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNext-generation Risk Assessment (NGRA)pt_PT
dc.subjectAvaliação de Risco de Última Geraçãopt_PT
dc.subjectChemicalspt_PT
dc.subjectQuímicospt_PT
dc.subjectSafety Assessmentpt_PT
dc.subjectAvaliação de Segurançapt_PT
dc.subjectExposure Assessmentpt_PT
dc.subjectAvaliação da Exposiçãopt_PT
dc.subjectHazard Characterisationpt_PT
dc.subjectCaracterização do Riscopt_PT
dc.subjectHuman Biomonitoring (HBM)pt_PT
dc.subjectBiomonitorização Humanapt_PT
dc.subjectNew Approach Methods (NAM)pt_PT
dc.subjectNovas Abordagens Metodológicaspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectToxicologypt_PT
dc.subjectToxicologiapt_PT
dc.subjectDeterminants of health and diseasept_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectRisk Assessmentpt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectPARCpt_PT
dc.subjectPartnership for the Assessment of Risks from Chemicalspt_PT
dc.subjectEurope
dc.titleA walk in the PARC: developing and implementing 21st century chemical risk assessment in Europept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage908pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage893pt_PT
oaire.citation.titleArchives of Toxicologypt_PT
oaire.citation.volume97pt_PT
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person.givenNameMaria Joao
person.givenNameJan
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