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Effects of titanium dioxide nanoparticles in human gastric epithelial cells in vitro

2013-08-23Journal article Restricted access
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dc.contributor.authorBotelho, M.C.
dc.contributor.authorCosta, C.
dc.contributor.authorSilva, S.
dc.contributor.authorCosta, S.
dc.contributor.authorDhawan, A.
dc.contributor.authorOliveira, P.A.
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2013-11-18T15:58:22Z
dc.date.available2013-11-18T15:58:22Z
dc.date.issued2013-08-23
dc.description.abstractManufacturing or using nanomaterials may result in exposure of workers to nanoparticles. Potential routes of exposure include skin, lung and gastrointestinal tract. The lack of health-based standards for nanomaterials combined with their increasing use in many different workplaces and products emphasize the need for a reliable temporary risk assessment tool. Therefore, the aim of this work was to explore the effects of different doses of titanium dioxide nanoparticles on human gastric epithelial cells in vitro. We analyzed proliferation by MTT assay, apoptosis by Tunel, migration by injury assay, oxidative stress by determining GSH/GSSG ratio and DNA damage by Comet assay on nanoparticle-treated AGS human gastric epithelial cell line in comparison to controls. We show and discuss the tumor-like phenotypes of nanoparticles-exposed AGS cells in vitro, as increased proliferation and decreased apoptosis. Our results demonstrate for the first time that nanoparticles induce tumor-like phenotypes in human gastric epithelial cells.por
dc.identifier.citationBiomed Pharmacother. 2014 Feb;68(1):59-64. doi: 10.1016/j.biopha.2013.08.006. Epub 2013 Aug 23por
dc.identifier.issn0753-3322
dc.identifier.otherdoi.org/10.1016/j.biopha.2013.08.006
dc.identifier.urihttp://hdl.handle.net/10400.18/1780
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0753332213000954por
dc.subjectApoptosispor
dc.subjectGastric Epithelial ellspor
dc.subjectGenotoxicitypor
dc.subjectOxidative Stresspor
dc.subjectProliferationpor
dc.subjectTiO(2) nanoparticlespor
dc.titleEffects of titanium dioxide nanoparticles in human gastric epithelial cells in vitropor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBiomedicine and Pharmacotherapypor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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