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Are iron oxide nanoparticles safe? Current knowledge and future perspectives

2016-03-31Journal article Restricted access
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dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorFernández-Bertólez, Natalia
dc.contributor.authorKiliç, Gözde
dc.contributor.authorCosta, Carla
dc.contributor.authorCosta, Solange
dc.contributor.authorFraga, Sonia
dc.contributor.authorBessa, Maria Joao
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorLaffon, Blanca
dc.date.accessioned2016-10-20T14:18:26Z
dc.date.available2020-04-01T00:30:12Z
dc.date.issued2016-03-31
dc.description.abstractDue to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible - mainly on the basis of viability tests results - influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.pt_PT
dc.description.sponsorshipThis work was supported byXunta de Galicia (EM 2012/079), the project NanoToxClass (ERA ERA-SIINN/001/2013), and by TD1204 MODENA COST Action.pt_PT
dc.identifier.citationJ Trace Elem Med Biol. 2016 Dec;38:53-63. doi: 10.1016/j.jtemb.2016.03.017. Epub 2016 Mar 31pt_PT
dc.identifier.doi10.1016/j.jtemb.2016.03.017pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4063
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEstablishing nanomaterial grouping/ classification strategies according to toxicity and biological effects for supporting risk assessment
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0946672X16300530pt_PT
dc.subjectIron Oxide Nanoparticlespt_PT
dc.subjectIn vivo Studiespt_PT
dc.subjectIn vitro Studiespt_PT
dc.subjectEpidemiological Studiespt_PT
dc.subjectToxicitypt_PT
dc.subjectToxicologiapt_PT
dc.titleAre iron oxide nanoparticles safe? Current knowledge and future perspectivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEstablishing nanomaterial grouping/ classification strategies according to toxicity and biological effects for supporting risk assessment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/ERA-SIINN%2F0001%2F2013/PT
oaire.citation.endPage63pt_PT
oaire.citation.startPage53pt_PT
oaire.citation.titleJournal of Trace Elements in Medicine and Biologypt_PT
oaire.citation.volume38pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationa118e28a-71df-4d9f-b18c-9d4e164baf22
relation.isProjectOfPublication.latestForDiscoverya118e28a-71df-4d9f-b18c-9d4e164baf22

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