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Performance of surveillance case definitions for respiratory syncytial virus infections through the sentinel influenza surveillance system, Portugal, 2010 to 2018

2019-11-07Journal article Open access
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dc.contributor.authorSáez-López, Emma
dc.contributor.authorPechirra, Pedro
dc.contributor.authorCosta, Inês
dc.contributor.authorCristóvão, Paula
dc.contributor.authorConde, Patrícia
dc.contributor.authorMachado, Ausenda
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorGuiomar, Raquel
dc.date.accessioned2020-05-05T22:41:21Z
dc.date.available2020-05-05T22:41:21Z
dc.date.issued2019-11-07
dc.description.abstractBackground: Well-established influenza surveillance systems (ISS) can be used for respiratory syncytial virus (RSV) surveillance. In Portugal, RSV cases are detected through the ISS using the European Union (EU) influenza-like illness (ILI) case definition. Aim: To investigate clinical predictors for RSV infection and how three case definitions (EU ILI, a modified EU acute respiratory infection, and one respiratory symptom) performed in detecting RSV infections in Portugal. Methods: This observational retrospective study used epidemiological and laboratory surveillance data (October 2010–May 2018). Associations between clinical characteristics and RSV detection were analysed using logistic regression. Accuracy of case definitions was assessed through sensitivity, specificity, and area under the receiver operating characteristic curve (AUC). A 0.05 significance level was accepted. Results: The study involved 6,523 persons, including 190 (2.9%) RSV cases. Among 183 cases with age information, RSV infection was significantly more frequent among individuals < 5 years (n = 23; 12.6%) and ≥ 65 years (n = 45; 24.6%) compared with other age groups (p < 0.0001). Cough (odds ratio (OR): 2.4; 95% confidence interval (CI): 1.2–6.5) was the best RSV-infection predictor considering all age groups, while shortness of breath was particularly associated with RSV-positivity among ≤ 14 year olds (OR: 6.7; 95% CI: 2.6–17.4 for 0–4 year olds and OR: 6.7; 95% CI: 1.5–28.8 for 5–14 year olds). Systemic symptoms were significantly associated with RSV-negative and influenza-positive cases. None of the case definitions were suitable to detect RSV infections (AUC = 0.51). Conclusion: To avoid underestimating the RSV disease burden, RSV surveillance within the Portuguese sentinel ISS would require a more sensitive case definition than ILI and, even a different case definition according to age.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2019 Nov 7;24(45):pii=1900140. doi: 10.2807/1560-7917.ES.2019.24.45.1900140pt_PT
dc.identifier.doi10.2807/1560-7917.ES.2019.24.45.1900140pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/6597
dc.language.isoengpt_PT
dc.publisherEuropean Centre for Disease Prevention and Controlpt_PT
dc.relation.publisherversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.45.1900140pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectRespiratory Syncytial Viruspt_PT
dc.subjectSentinel Influenza Surveillance Systempt_PT
dc.subjectCase Definitionpt_PT
dc.subjectClinical Predictorspt_PT
dc.subjectPortugalpt_PT
dc.titlePerformance of surveillance case definitions for respiratory syncytial virus infections through the sentinel influenza surveillance system, Portugal, 2010 to 2018pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue45pt_PT
oaire.citation.startPagepii=1900140pt_PT
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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