An integrative system biology approach to delineate complex genotype-phenotype associations in Autism Spectrum Disorder

Asif, M.; Martiniano, Hugo F.; Rasga, Célia; Marques, Ana R.; Santos, João X.; Couto, Francisco M.; Vicente, Astrid M.

http://hdl.handle.net/10400.18/4851

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Resumo(s)

Objectives: The global objective of the study is to improve the current knowledge on ASD prognosis and diagnosis by delineating the complex genotype-phenotype associations using an integrative systems biology approach. For this purpose three specific objectives were pursued: - To identify clinically similar subgroups of individuals with ASD; - To find biological processes disrupted by rare CNVs targeting brain genes in ASD subjects; - To train a machine learning classifier for the clinical prediction of disease progression from genetic information in very young children.

Palavras-chave

Autism Spectrum Disorder Perturbações do Desenvolvimento Infantil e Saúde Mental Autismo

URI

http://hdl.handle.net/10400.18/4851

Editora

Instituto Nacional de Saúde Doutor Ricardo Jorge, IP

Coleções

DPSPDNT - Posters/abstracts em congressos internacionais

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