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Allergy: Evaluation of 16 years (2007–2022) results of the shared external quality assessment program in Belgium, Finland, Portugal and The Netherlands

2023-11-28Journal article Restricted access
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dc.contributor.authorHeron, Michiel
dc.contributor.authorSchreurs, Marco W.J.
dc.contributor.authorHaagen, Inez-Anne
dc.contributor.authorChina, Bernard
dc.contributor.authorFaria, Ana Paula
dc.contributor.authorVanhanen, Anna-Riitta
dc.contributor.authorThelen, Marc
dc.contributor.authorWeykamp, Cas W.
dc.date.accessioned2024-01-04T16:00:00Z
dc.date.available2024-11-29T01:30:34Z
dc.date.issued2023-11-28
dc.description.abstractObjectives: This paper evaluates 16 year results of the Allergy EQA program shared by EQA organisers in Belgium, Finland, Portugal, and The Netherlands. Methods: The performance of Thermo Fisher and Siemens user groups (in terms of concordance between both groups, between laboratory CV, prevalence of clinically significant errors) and suitability of samples (stability and validity of dilution of patient samples) are evaluated using data of 192 samples in the EQA programs from 2007 to 2022. Measurands covered are total IgE, screens and mixes, specific IgE extracts and allergen components. Results: There is perfect (53 %), acceptable (40 %) and poor (6 %) concordance between both method groups. In case of poor concordance the best fit with clinical data is seen for Thermo Fisher (56 %) and Siemens (26 %) respectively. The between laboratory CV evolves from 7.8 to 6.6 % (Thermo Fisher) and 7.3 to 7.7 % (Siemens). The prevalence of blunders by individual laboratories is stable for Siemens (0.4 %) and drops from 0.4 to 0.2 % for Thermo Fisher users. For IgE, the between year CV of the mean of both user groups is 1 %, and a fifteen-fold dilution of a patient sample has an impact of 2 and 4 % on the recovery of Thermo Fisher and Siemens user groups. Conclusions: The analytical performance of Thermo Fisher is slightly better than that of Siemens users but the clinical impact of this difference is limited. Stability of the sample and the low impact of dilution on the recovery of measurands demonstrates the suitability for purpose of the EQA program.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Chem Lab Med. 2023 Nov 28. doi: 10.1515/cclm-2023-0862. Online ahead of print.pt_PT
dc.identifier.doi10.1515/cclm-2023-0862pt_PT
dc.identifier.issn1434-6621
dc.identifier.urihttp://hdl.handle.net/10400.18/8852
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDe Gruyterpt_PT
dc.relation.publisherversionhttps://www.degruyter.com/document/doi/10.1515/cclm-2023-0862/htmlpt_PT
dc.subjectAllergypt_PT
dc.subjectEQA Programpt_PT
dc.subjectAEQpt_PT
dc.subjectBetween Laboratory CVpt_PT
dc.subjectSample Qualitypt_PT
dc.subjectExternal Quality Assessmentpt_PT
dc.subjectThermo Fisherpt_PT
dc.subjectSiemenspt_PT
dc.subjectPrograma Nacional de Avaliação Externa da Qualidadept_PT
dc.subjectPNAEQpt_PT
dc.subjectAlergiaspt_PT
dc.subjectAvaliação Externa da Qualidadept_PT
dc.titleAllergy: Evaluation of 16 years (2007–2022) results of the shared external quality assessment program in Belgium, Finland, Portugal and The Netherlandspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleClinical Chemistry and Laboratory Medicine (CCLM)pt_PT
person.familyNameHeron
person.familyNameChina
person.familyNameFaria
person.familyNameThelen
person.givenNameMichiel
person.givenNameBernard
person.givenNameAna Paula
person.givenNameMarc
person.identifier.orcid0000-0003-0576-8652
person.identifier.orcid0000-0001-5717-478X
person.identifier.orcid0009-0003-8859-181X
person.identifier.orcid0000-0002-4931-4436
person.identifier.ridI-6372-2017
person.identifier.scopus-author-id6701415089
rcaap.embargofctAcesso de acordo com a política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication66ab0cef-a4ff-42af-899b-bd7eff7f51db
relation.isAuthorOfPublication62276411-67e8-41f1-8025-28e95cfd8b09
relation.isAuthorOfPublication5f6aaa09-79b5-4615-9de2-99504ee180aa
relation.isAuthorOfPublication21f9b97d-edfd-4bf1-9b86-2ddfbb5b89af
relation.isAuthorOfPublication.latestForDiscovery5f6aaa09-79b5-4615-9de2-99504ee180aa

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