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Hepatitis C in a Mobile Low-Threshold Methadone Program

2017-06-01Journal article Restricted access
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dc.contributor.authorSilva, Mário J
dc.contributor.authorPereira, Cláudia
dc.contributor.authorLoureiro, Rafaela
dc.contributor.authorBalsa, Catarina
dc.contributor.authorLopes, Paulo
dc.contributor.authorÁgua-Doce, Ivone
dc.contributor.authorBelo, Elsa
dc.contributor.authorMartins, Helena C
dc.contributor.authorCoutinho, Rodrigo
dc.contributor.authorPádua, Elizabeth
dc.date.accessioned2018-03-08T12:53:04Z
dc.date.available2018-03-08T12:53:04Z
dc.date.issued2017-06-01
dc.description.abstractIntroduction: Data on the epidemiology of hepatitis C among individuals who use drugs in low-threshold settings are lacking, although crucial to assess the burden of disease and aid in the design of treatment strategies. Objective: The aim of this study was to characterize the epidemiology and disease related to hepatitis C in a population attending a low-threshold methadone program. Materials and methods: A cross-sectional study in the population attending the Mobile Low-Threshold Methadone Program in Lisbon, Portugal, was carried out. The survey included assessment of risk factors for infection with hepatitis C virus (HCV) and liver disease, HCV serology and RNA detection, HCV genotyping, and liver disease staging. Results: A total of 825 participants were enrolled, 81.3% men, mean age 44.5 years. Injecting drug use (IDU) was reported by 58.4% – among these, 28.2% were people who inject drugs. Excessive drinking and HIV coinfection were reported by 33.4 and 15.9%, respectively. Among participants with active infection, 16.9% were followed up in hospital consultation. The overall seroprevalence for HCV was 67.6% (94.2% in IDU, 30.0% in non-IDU, 97.1% in people who inject drugs, and 75.6% in excessive drinkers). Among seropositives for HCV, active infection was present in 68.4%. Among individuals with active infection, the most common genotypes were 1a (45.3%) and 3a (28.7%), whereas 30% had severe liver fibrosis or cirrhosis. Age 45 years or older, HCV genotype 3, and coinfection with HIV were significant predictors of cirrhosis. Conclusion: This population has a high burden of hepatitis C and several characteristics that favor dissemination of infection. Healthcare strategies are urgently needed to address hepatitis C in this setting.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Gastroenterol Hepatol. 2017 Jun;29(6):657-662. doi: 10.1097/MEG.0000000000000843.pt_PT
dc.identifier.doi10.1097/MEG.0000000000000843pt_PT
dc.identifier.issn0954-691X
dc.identifier.urihttp://hdl.handle.net/10400.18/5370
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott, Williams & Wilkinspt_PT
dc.relation.publisherversionhttps://insights.ovid.com/pubmed?pmid=28151750pt_PT
dc.subjectHepatitis Cpt_PT
dc.subjectMethadonept_PT
dc.subjectOpioid-Related Disorderspt_PT
dc.subjectPortugalpt_PT
dc.subjectSeroepidemiologic Studiespt_PT
dc.subjectDrug Userspt_PT
dc.subjectOpiate Substitution Treatmentpt_PT
dc.subjectHepatitis C Diagnosispt_PT
dc.subjectInfecções Sexualmente Transmissíveispt_PT
dc.titleHepatitis C in a Mobile Low-Threshold Methadone Programpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage662pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage657pt_PT
oaire.citation.titleEuropean Journal of Gastroenterology and Hepatologypt_PT
oaire.citation.volume29pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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