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Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection

2022-10-20Journal article Open access
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dc.contributor.authorLipari Pinto, Patrícia
dc.contributor.authorFlorindo, Cristina
dc.contributor.authorJaneiro, Patrícia
dc.contributor.authorSantos, Rita Loureiro
dc.contributor.authorMexia, Sandra
dc.contributor.authorRocha, Hugo
dc.contributor.authorTavares de Almeida, Isabel
dc.contributor.authorVilarinho, Laura
dc.contributor.authorGaspar, Ana
dc.date.accessioned2023-03-08T15:14:55Z
dc.date.available2023-03-08T15:14:55Z
dc.date.issued2022-10-20
dc.description.abstractThe early diagnosis of and intervention in vitamin B12 deficiency in exclusively breastfed infants by mothers with low vitamin B12 is crucial in preventing possible irreversible neurologic damage, megaloblastic anemia, and failure to thrive. We assess the usefulness of the early detection of asymptomatic B12 deficiency related to acquired conditions and highlight the importance of monitoring serum vitamin B12 levels during pregnancy. We describe demographic, clinical, dietary, and biochemical data, including the evolution of a vitamin B12 deficiency's functional biomarkers. We enrolled 12 newborns (5 males) with an age range of 1-2 months old that were exclusively breastfed and asymptomatic. These cases were referred to our metabolic unit due to alterations in expanded newborn screening: high levels of methylmalonic acid and/or total homocysteine (tHcy). All mothers were under a vegetarian diet except three who had abnormal B12 absorption, and all presented low or borderline serum B12 level and high plasma levels of tHcy. Supplementation with oral vitB12 re-established the metabolic homeostasis of the mothers. In infants, therapy with an intramuscular injection of 1.0 mg hydroxocobalamin led to the rapid normalization of the metabolic pattern, and a healthy outcome was observed. Acquired B12 deficiency should be ruled out before proceeding in a differential diagnosis of cobalamin metabolism deficits, methylmalonic acidemia, and homocystinuria.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients. 2022 Oct 20;14(20):4397. doi: 10.3390/nu14204397.pt_PT
dc.identifier.doi10.3390/nu14204397pt_PT
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.18/8550
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/14/20/4397pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMethylmalonic Acidpt_PT
dc.subjectNewborn Screeningpt_PT
dc.subjectPregnancypt_PT
dc.subjectTotal Homocysteinept_PT
dc.subjectVitamin B12 Deficiencypt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleAcquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue20pt_PT
oaire.citation.startPage4397pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume14pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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