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Nonsense-mediated RNA decay and its bipolar function in cancer

2021-04-29Journal article Open access
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dc.contributor.authorNogueira, Gonçalo
dc.contributor.authorFernandes, Rafael
dc.contributor.authorGarcía-Moreno, Juan F
dc.contributor.authorRomão, Luísa
dc.date.accessioned2022-02-07T16:26:56Z
dc.date.available2022-02-07T16:26:56Z
dc.date.issued2021-04-29
dc.descriptionReviewpt_PT
dc.description.abstractNonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. The present review aims to discuss the paradoxical, pro- and anti-tumorigenic roles of NMD, and how cancer cells have exploited both functions to potentiate the disease. Considering recent genetic and bioinformatic studies, we also provide a comprehensive overview of the present knowledge of the advantages and disadvantages of different NMD modulation-based approaches in cancer therapy, reflecting on the challenges imposed by the complexity of this disease. Furthermore, we discuss significant advances in the recent years providing new perspectives on the implications of aberrant NMD-escaping frameshifted transcripts in personalized immunotherapy design and predictive biomarker optimization. A better understanding of how NMD differentially impacts tumor cells according to their own genetic identity will certainly allow for the application of novel and more effective personalized treatments in the near future.pt_PT
dc.description.sponsorshipGonçalo Nogueira, Rafael Fernandes, and Juan Fernandez García-Moreno are recipients of a fellowship from BioSys PhD programme PD65-2012 (SFRH/PD/BD/130959/2017, SFRH/BD/114392/2016 and SFRH/PD/BD/142898/2018, respectively) from FCT. This work was partially supported by UID/MULTI/04046/2019 Research Unit grant (to BioISI).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMol Cancer. 2021 Apr 29;20(1):72. doi: 10.1186/s12943-021-01364-0. Reviewpt_PT
dc.identifier.doi10.1186/s12943-021-01364-0pt_PT
dc.identifier.issn1476-4598
dc.identifier.urihttp://hdl.handle.net/10400.18/7941
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationSFRH/PD/BD/130959/2017pt_PT
dc.relationSFRH/BD/114392/2016pt_PT
dc.relationSFRH/PD/BD/142898/2018pt_PT
dc.relationBiosystems & Integrative Sciences Institute
dc.relation.publisherversionhttps://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-021-01364-0.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerpt_PT
dc.subjectCancer Therapypt_PT
dc.subjectEnvironmental Stresspt_PT
dc.subjectImmunotherapypt_PT
dc.subjectNeoantigenpt_PT
dc.subjectNonsense-mediated RNA Decay (NMD)pt_PT
dc.subjectOncogenept_PT
dc.subjectTumor Microenvironmentpt_PT
dc.subjectTumor Suppressor Genept_PT
dc.subjectDoenças Genéticaspt_PT
dc.subjectGenómica Funcionalpt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.titleNonsense-mediated RNA decay and its bipolar function in cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems & Integrative Sciences Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04046%2F2019/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage72pt_PT
oaire.citation.titleMolecular Cancerpt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRomão
person.givenNameLuísa
person.identifierhttps://scholar.google.pt/citations?hl=pt-PT&user=CAHjIsoAAAAJ&cstart=60&pagesize=20
person.identifier.ciencia-idEB19-DF07-EB37
person.identifier.orcid0000-0002-5061-5287
person.identifier.scopus-author-idhttp://www.scopus.com/authid/detail.url?authorId=6602834878
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione2eb8254-24ed-4bfc-b478-3e9022f729e2
relation.isAuthorOfPublication.latestForDiscoverye2eb8254-24ed-4bfc-b478-3e9022f729e2
relation.isProjectOfPublication35168786-8dfc-4a00-9759-dab3669fe1ae
relation.isProjectOfPublication.latestForDiscovery35168786-8dfc-4a00-9759-dab3669fe1ae

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