Repository logo
 
Publication

Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project

2000-10Journal article Restricted access
Simple item page
dc.contributor.authorSchiele, F.
dc.contributor.authorDe Bacquer, D.
dc.contributor.authorVincent-Viry, M.
dc.contributor.authorBeisiegel, U.
dc.contributor.authorEhnholm, C.
dc.contributor.authorEvans, A.
dc.contributor.authorKafatos, A.
dc.contributor.authorMartins, M.C.
dc.contributor.authorSans, S.
dc.contributor.authorSass, C.
dc.contributor.authorVisvikis, S.
dc.contributor.authorDe Backer, G.
dc.contributor.authorSiest, G.
dc.date.accessioned2012-03-12T12:45:37Z
dc.date.available2012-03-12T12:45:37Z
dc.date.issued2000-10
dc.descriptionThe ApoEurope group, collaborating centres, and their associated investigators: Portugal: Unidade de Química Clinica, Instituto Nacional de Saúde, Lisboa: Maria do Carmo Martins, Maria Odete Rodrigues, Maria Isabel Albergaria, Maria Liseta Alpendrepor
dc.description.abstractAs part of the ApoEurope Project, the apolipoprotein E (apo E) serum concentration and polymorphism were determined in 6934 healthy subjects aged 25-64 years recruited in six European countries: Finland; France; Greece; Northern Ireland; Portugal and Spain. Age and sex influenced apo E concentration with concentrations being significantly higher in men than in women for those aged between 25 and 44 years. The age effect differed between the sexes after the age of 44 years, displaying a linear increase in women and a plateau in men. As expected, the serum apo E concentration was highest in varepsilon2 carriers and lowest in varepsilon4 carriers in each country with a significantly higher frequency of the varepsilon4 allele in the northern regions. The main finding of this study was a clear increasing North-South gradient in serum apo E concentration independent of age, sex and apo E genotype. In subjects aged <45 years and with the varepsilon3/varepsilon3 genotype, apo E concentration was higher in the South-East (Greece) as compared to the North by 20% for men and 32% for women. In addition to the genetic polymorphism, the geographical area is an important factor to take into account when studying serum apo E concentration in multicentre studies and defining reference values.por
dc.identifier.citationAtherosclerosis. 2000 Oct;152(2):475-88.por
dc.identifier.issn0021-9150
dc.identifier.otherdoi:10.1016/S0021-9150(99)00501-8
dc.identifier.urihttp://hdl.handle.net/10400.18/734
dc.language.isoengpor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0021915099005018por
dc.subjectApolipoprotein E polymorphismpor
dc.subjectApolipoprotein E concentrationpor
dc.subjectMulticentre Studypor
dc.subjectEpidemiologypor
dc.subjectCardiovascular Riskpor
dc.subjectDoenças Cardio e Cérebro-vascularespor
dc.titleApolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Projectpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage488por
oaire.citation.startPage475por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Apolipoprotein E serum concentration and polymorphism in six European countries the ApoEurope Project.pdf
Size:
158.66 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DPSPDNT - Artigos em revistas internacionais