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Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

2022-08Journal article Open access
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dc.contributor.authorIsidro, Joana
dc.contributor.authorBorges, Vítor
dc.contributor.authorPinto, Miguel
dc.contributor.authorSobral, Daniel
dc.contributor.authorSantos, João Dourado
dc.contributor.authorNunes, Alexandra
dc.contributor.authorMixão, Verónica
dc.contributor.authorFerreira, Rita
dc.contributor.authorSantos, Daniela
dc.contributor.authorDuarte, Silvia
dc.contributor.authorVieira, Luís
dc.contributor.authorBorrego, Maria José
dc.contributor.authorNúncio, Sofia
dc.contributor.authorde Carvalho, Isabel Lopes
dc.contributor.authorPelerito, Ana
dc.contributor.authorCordeiro, Rita
dc.contributor.authorGomes, João Paulo
dc.date.accessioned2023-01-30T13:32:45Z
dc.date.available2023-01-30T13:32:45Z
dc.date.issued2022-08
dc.descriptionTrabalho distinguido com o Prémio João Monjardino 2022.pt_PT
dc.descriptionhttps://www.insa.min-saude.pt/investigadora-do-instituto-ricardo-jorge-vence-premio-joao-monjardino-2022/
dc.descriptions41591-022-02036-2_
dc.descriptionErratum in: Nat Med. 2022 Oct;28(10):2220-2221. doi: 10.1038/s41591-022-02036-2.
dc.description.abstractThe largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 2022 (refs. 1-6). In this study, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with 2018-2019 cases linked to an endemic country, it segregates in a divergent phylogenetic branch, likely reflecting continuous accelerated evolution. An in-depth mutational analysis suggests the action of host APOBEC3 in viral evolution as well as signs of potential MPXV human adaptation in ongoing microevolution. Our findings also indicate that genome sequencing may provide resolution to track the spread and transmission of this presumably slow-evolving double-stranded DNA virus.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNat Med. 2022 Aug;28(8):1569-1572. doi: 10.1038/s41591-022-01907-y. Epub 2022 Jun 24.pt_PT
dc.identifier.doi10.1038/s41591-022-01907-ypt_PT
dc.identifier.issn1078-8956
dc.identifier.urihttp://hdl.handle.net/10400.18/8471
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Researchpt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41591-022-01907-ypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMonkeypoxpt_PT
dc.subjectMonkeypox Viruspt_PT
dc.subjectMonkeypox / geneticspt_PT
dc.subjectMonkeypox / epidemiologypt_PT
dc.subjectPhylogenypt_PT
dc.subjectZoonotic Disease
dc.subjectDisease Outbreaks
dc.subjectHumans
dc.subjectInfecções Sistémicas e Zoonoses
dc.titlePhylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox viruspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1572pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1569pt_PT
oaire.citation.titleNature Medicinept_PT
oaire.citation.volume28pt_PT
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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