Publication
Cardiovascular Risk of Children With Clinical Diagnosis of Familial Hypercholesterolemia
| dc.contributor.author | Alves, A.C. | |
| dc.contributor.author | Medeiros, A.M. | |
| dc.contributor.author | Bourbon, M. | |
| dc.date.accessioned | 2012-01-17T16:16:23Z | |
| dc.date.available | 2012-01-17T16:16:23Z | |
| dc.date.issued | 2011-07 | |
| dc.description.abstract | Familial hypercholesterolemia (FH) is an inherited disorder of cholesterol metabolism, clinically characterized by high levels of LDL-associated cholesterol in plasma leading to accelerated atherosclerosis and increased risk of premature coronary heart disease (CHD). FH results from mutations in three genes involved in lipid metabolism: LDLR, APOB, PCSK9. Molecular identification of these patients can reduce the burden of mortality from cardiovascular disorders simply by the correct identification of the disease early in life, followed by counselling on appropriate lifestyle modifications and therapeutic measures when required. The aim of the Portuguese FH Study (PFHS) is to identify FH patients in order to prevent the development of premature CHD. From 563 index patients sent for the study, 153 are children. The aim of this study was to analyse the data from children with and without genetically diagnosis of FH recruited for the PFHS concerning their BMI. | por |
| dc.description.sponsorship | Ana Catarina Alves was funded by FCT SFRH / BD / 27990 / 2006; Ana Margarida Medeiros was funded by Portuguese Society of Cardiology project grant FCT PIC/IC/83333/2007; project grant from Portuguese Society of Cardiology 2006-2009 and 2010-2012 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.18/387 | |
| dc.language.iso | eng | por |
| dc.publisher | Instituto Nacional de Saúde Doutor Ricardo Jorge, IP | por |
| dc.subject | Doenças Cardio e Cérebro-vasculares | por |
| dc.title | Cardiovascular Risk of Children With Clinical Diagnosis of Familial Hypercholesterolemia | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Lisboa, Portugal | por |
| oaire.citation.title | International Conference on Childhood Obesity(CIO), 6 a 9 de Julho 2011 | por |
| rcaap.rights | embargoedAccess | por |
| rcaap.type | conferenceObject | por |
Files
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- Cardiovascular risk of children.pdf
- Size:
- 726.23 KB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: