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Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants

2022-06-01Journal article Open access
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dc.contributor.authorGilles, Liese
dc.contributor.authorGovarts, Eva
dc.contributor.authorRodriguez Martin, Laura
dc.contributor.authorAndersson, Anna-Maria
dc.contributor.authorAppenzeller, Brice M.R.
dc.contributor.authorBarbone, Fabio
dc.contributor.authorCastano, Argelia
dc.contributor.authorCoertjens, Dries
dc.contributor.authorDen Hond, Elly
dc.contributor.authorDzhedzheia, Vazha
dc.contributor.authorEržen, Ivan
dc.contributor.authorEsteban, Marta
dc.contributor.authorFábelová, Lucia
dc.contributor.authorFillol, Clémence
dc.contributor.authorFranken, Carmen
dc.contributor.authorFrederiksen, Hanne
dc.contributor.authorGabriel, Catherine
dc.contributor.authorHaug, Line Småstuen
dc.contributor.authorHorvat, Milena
dc.contributor.authorHalldórsson, Thórhallur Ingi
dc.contributor.authorJanasik, Beata
dc.contributor.authorHolcer, Nataša Janev
dc.contributor.authorKakucs, Réka
dc.contributor.authorKarakitsios, Spyros
dc.contributor.authorKatsonouri, Andromachi
dc.contributor.authorKlánová, Jana
dc.contributor.authorKold-Jensen, Tina
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorKonstantinou, Corina
dc.contributor.authorKoponen, Jani
dc.contributor.authorLignell, Sanna
dc.contributor.authorLindroos, Anna Karin
dc.contributor.authorMakris, Konstantinos C.
dc.contributor.authorMazej, Darja
dc.contributor.authorMorrens, Bert
dc.contributor.authorMurínová, Ľubica Palkovičová
dc.contributor.authorNamorado, Sónia
dc.contributor.authorPedraza-Diaz, Susana
dc.contributor.authorPeisker, Jasmin
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorRambaud, Loïc
dc.contributor.authorRosolen, Valentina
dc.contributor.authorRucic, Enrico
dc.contributor.authorRüther, Maria
dc.contributor.authorSarigiannis, Dimosthenis
dc.contributor.authorTratnik, Janja Snoj
dc.contributor.authorStandaert, Arnout
dc.contributor.authorStewart, Lorraine
dc.contributor.authorSzigeti, Tamás
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorTolonen, Hanna
dc.contributor.authorEiríksdóttir, Ása
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorVerheyen, Veerle J.
dc.contributor.authorVlaanderen, Jelle
dc.contributor.authorVogel, Nina
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorWeber, Till
dc.contributor.authorZock, Jan-Paul
dc.contributor.authorSepai, Ovnair
dc.contributor.authorSchoeters, Greet
dc.date.accessioned2022-12-05T12:34:29Z
dc.date.available2022-12-05T12:34:29Z
dc.date.issued2022-06-01
dc.description.abstractHuman biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern and to evaluate the success of chemical policies. Europe has launched the ambitious REACH program in 2007 to improve the protection of human health and the environment. In October 2020 the EU commission published its new chemicals strategy for sustainability towards a toxic-free environment. The European Parliament called upon the commission to collect human biomonitoring data to support chemical’s risk assessment and risk management. This manuscript describes the organization of the first HBM4EU-aligned studies that obtain comparable human biomonitoring (HBM) data of European citizens to monitor their internal exposure to environmental chemicals. The HBM4EU-aligned studies build on existing HBM capacity in Europe by aligning national or regional HBM studies. The HBM4EU-aligned studies focus on three age groups: children, teenagers, and adults. The participants are recruited between 2014 and 2021 in 11 to 12 primary sampling units that are geographically distributed across Europe. Urine samples are collected in all age groups, and blood samples are collected in children and teenagers. Auxiliary information on sociodemographics, lifestyle, health status, environment, and diet is collected using questionnaires. In total, biological samples from 3137 children aged 6–12 years are collected for the analysis of biomarkers for phthalates, HEXAMOLL® DINCH, and flame retardants. Samples from 2950 teenagers aged 12–18 years are collected for the analysis of biomarkers for phthalates, Hexamoll® DINCH, and per and polyfluoroalkyl substances (PFASs), and samples from 3522 adults aged 20–39 years are collected for the analysis of cadmium, bisphenols, and metabolites of polyaromatic hydrocarbons (PAHs). The children’s group consists of 50.4% boys and 49.5% girls, of which 44.1% live in cities, 29.0% live in towns/suburbs, and 26.8% live in rural areas. The teenagers’ group includes 50.6% girls and 49.4% boys, with 37.7% of residents in cities, 31.2% in towns/suburbs, and 30.2% in rural areas. The adult group consists of 52.6% women and 47.4% men, 71.9% live in cities, 14.2% in towns/suburbs, and only 13.4% live in rural areas. The study population approaches the characteristics of the general European population based on age-matched EUROSTAT EU-28, 2017 data; however, individuals who obtained no to lower educational level (ISCED 0–2) are under represented. The data on internal human exposure to priority chemicals from this unique cohort will provide a baseline for Europe’s strategy towards a non-toxic environment and challenges and recommendations to improve the sampling frame for future EU-wide HBM surveys are discussed.pt_PT
dc.description.sponsorshipThe HBM4EU initiative is co-financed under Horizon 2020 (grant agreement No 733032). Additional financial support for the conduct of the studies is provided by each participating country. More information on co-funding of the individual studies is provided in Supplementary Materials, Table S14.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Environ Res Public Health. 2022 Jun 1;19(11):6787. doi: 10.3390/ijerph19116787pt_PT
dc.identifier.doi10.3390/ijerph19116787pt_PT
dc.identifier.issn1660-4601
dc.identifier.urihttp://hdl.handle.net/10400.18/8377
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/19/11/6787pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHBM4EUpt_PT
dc.subjectAligned Studiespt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectEuropept_PT
dc.subjectBiomonitorização Humanapt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.subjectObservação em Saúde e Vigilânciapt_PT
dc.subjectINSEF-ExpoQuimpt_PT
dc.titleHarmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue11pt_PT
oaire.citation.startPage6787pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume19pt_PT
oaire.fundingStreamH2020
person.familyNameGilles
person.familyNameGovarts
person.familyNameRodriguez Martin
person.familyNameCastano
person.familyNameEsteban
person.familyNameNamorado
person.familyNamePedraza-Diaz
person.givenNameLiese
person.givenNameEva
person.givenNameLaura
person.givenNameArgelia
person.givenNameMarta
person.givenNameSónia
person.givenNameSusana
person.identifier.orcid0000-0002-3016-9750
person.identifier.orcid0000-0002-6075-4862
person.identifier.orcid0000-0001-6630-411X
person.identifier.orcid0000-0003-4152-7119
person.identifier.orcid0000-0002-4527-350X
person.identifier.orcid0000-0002-7500-8811
person.identifier.orcid0000-0001-9401-6473
person.identifier.ridD-7168-2015
person.identifier.ridF-3988-2018
person.identifier.scopus-author-id7005340777
person.identifier.scopus-author-id8677737500
person.identifier.scopus-author-id14047182500
person.identifier.scopus-author-id6602292613
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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