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Upregulation of RAC1/PAK1 signalling promotes DNA damage repair in colorectal cancer cells

2018-05Conference object Restricted access
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dc.contributor.authorBarros, Patricia
dc.contributor.authorAmaral, Andreia
dc.contributor.authorAbrantes, Leonor
dc.contributor.authorOliveira, Tiago
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria Joâo
dc.contributor.authorJordan, Peter
dc.contributor.authorGama Carvalho, Margarida
dc.contributor.authorMatos, Paulo
dc.date.accessioned2019-02-14T11:56:32Z
dc.date.available2020-06-01T00:30:16Z
dc.date.issued2018-05
dc.description.abstractIntroduction: Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in this type of cancers, particularly those with more aggressive and invasive features, which is frequently correlated with resistance to chemotherapeutics and unfavourable clinical prognosis. Previously, we described a new signalling pathway in which activation of RAC1/PAK1 signalling promotes a transcriptional switch between the BCL6 repressor and the STAT5 transcriptional activator at a restricted subset of gene promoters.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/5817
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectColorectal Cancerpt_PT
dc.subjectRAC1pt_PT
dc.subjectBCL6pt_PT
dc.subjectDNA Repairpt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.titleUpregulation of RAC1/PAK1 signalling promotes DNA damage repair in colorectal cancer cellspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title3rd ASPIC International Congress, Associação Portuguesa de Investigação em Cancro, 10-11 May 2018pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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