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Psychological impact of life events in systemic lupus erythematosus patients - Differences between flares and remission.

2024-07-21Research article Open access
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datacite.subject.fosCiências Médicas::Medicina Clínica
dc.contributor.authorFaria, Raquel
dc.contributor.authorGuimarães de Oliveira, Daniel
dc.contributor.authorAlves, Rute
dc.contributor.authorFarinha, Fátima
dc.contributor.authorPinho Costa, Paulo
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorFigueiredo-Braga, Margarida
dc.date.accessioned2025-04-03T15:10:47Z
dc.date.available2025-04-03T15:10:47Z
dc.date.issued2024-07-21
dc.description.abstractBackground: Stress has been linked to worsening symptoms and increased disease activity in patients with Systemic lupus erythematosus (SLE). Life-events are individual stress points, and there is conflicting evidence regarding their role in SLE activity and disease perception. Methods: Adult SLE patients were recruited for the study. Clinical and laboratory features of SLE were recorded, and previous diagnosis of anxiety or depression were retrieved from patients' electronic charts. Flares were defined by the Systemic Lupus Erythematosus Disease Activity (SLEDAI) flare Index, and flares during the previous year were documented. During a routine visit, they completed validated Portuguese translations of the 10-item Perceived Stress Scale (PSS-10), Hospital Anxiety and Depression Scale (HADS) and Life Experience Survey (LES) for the previous year. Results: A total of 47 female SLE patients were recruited. Ten patients (21.3%) had experienced recent flares. Patients with recent flares reported fewer life events, with lower positive, negative, and total weightings sums compared to those without recent flares. Although 42.2% of patients perceived pathological levels of stress in the previous month, 48.9% had anxiety symptoms, and 34% were at high risk for an anxiety disorder, these psychometric measures did not differ significantly between the recent flare and no-flare groups. Conclusions: There is a high prevalence of pathological levels of stress among SLE patients. SLE patients with recent flares report less psychological impact from life events, both positive and negative, independent of other psychological or pharmacological factors.eng
dc.description.sponsorshipDGO work is funded by a doctoral research grant from FCT – Foundation for Science and Technology (UI/BD/150742/2020); UMIB (UIDB/00215/2020; UIDP/00215/2020); ITR (LA/P/0064/2020).
dc.identifier.citationLupus. 2024 Sep;33(10):1139-1144. doi: 10.1177/09612033241266987. Epub 2024 Jul 21
dc.identifier.doi10.1177/09612033241266987
dc.identifier.issn1477-0962
dc.identifier.pmid39034640
dc.identifier.urihttp://hdl.handle.net/10400.18/10474
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSAGE Publications
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationUnit for Multidisciplinary Research in Biomedicine
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation.hasversionhttps://doi.org/10.1177/09612033241266987
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectPsychological Impact
dc.subjectFlare
dc.subjectLife-events
dc.subjectStress
dc.subjectSystemic Lupus Erythematosus
dc.subjectGenómica Funcional e Estrutural
dc.titlePsychological impact of life events in systemic lupus erythematosus patients - Differences between flares and remission.eng
dc.typeresearch article
dspace.entity.typePublication
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleUnit for Multidisciplinary Research in Biomedicine
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00215%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.endPage1144
oaire.citation.issue10
oaire.citation.startPage1139
oaire.citation.titleLupus
oaire.citation.volume33
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_b1a7d7d4d402bcce
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication5e782b2f-511f-446a-9c30-de1ea4f326df
relation.isProjectOfPublication3b59bbc6-7ac7-4600-b3e8-58aab73d3816
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication.latestForDiscovery5e782b2f-511f-446a-9c30-de1ea4f326df

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