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Nutraceuticals: a new therapeutic approach against

2011-09-07Conference object Open access
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dc.contributor.authorSantos, António Mário
dc.contributor.authorOleastro, Mónica
dc.contributor.authorVale de Gato, Inês
dc.contributor.authorLopes, Teresa
dc.contributor.authorSeixas, Elsa
dc.contributor.authorMachado, Jorge
dc.contributor.authorGuerreiro, António Sousa
dc.date.accessioned2012-01-12T15:21:05Z
dc.date.available2012-01-12T15:21:05Z
dc.date.issued2011-09-07
dc.description.abstractBackground and Aim: H. pylori induces severe gastric chronic inflammation and is the cause of gastritis, peptic ulcer and a major risk factor for gastric cancer. The aim of the study was to investigate the anti-inflammatory effect of two nutraceuticals in Hp-infected mucosa. Materials and Methods: Eighteen C57BL/6 mice were inoculated with Hp SS1 by gavage three times with 3 · 109 viable cells. Mice were then treated with either PBS, curcumin (10 mg/mouse) or Symbiotic 2000 (50 mg/mouse), three times per week. Half of the infected and three non-infected mice were euthanized at week 6, the remaining at week 18. Gastric samples were removed for immunohistochemistry and PCR array (inflammatory response and immunity pathway) analysis (Sabiosciences, Qiagen). Results: All the 18 mice were Hp positive by immunohistochemistry. The production of the chemokines CCL2, CCL5, CCL20, CCL25, CXCL1 and CXCL11 was significantly up-regulated at both week 6 (range of fold-change 4.3–718) and week 18 (range of fold-change 16–1192). Similarly, the expression of the proinflammatory cytokines IL-1b, IL6, IL9, IL10, IL23, TNFa and INFc was significantly augmented (range of fold-change 1338–8251). The treatment with either curcumin or symbiotic drastically decreased the expression of all these mediators, restoring their levels to those similar to the non-infected mice. Conclusions: The present study confirmed that Hp infection induces a strong inflammatory response. Curcumin and Symbiotic treatments exerted a significant anti-inflammatory effect in Hp-infected mucosa. The supplementation of diet with these nutraceuticals may be a novel clinical approach against gastric inflammation induced by Hp infection.por
dc.identifier.citationEuropean Helicobacter Study Group: Abstracts of the XXIVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer. Helicobacter 16 (Suppl. 1): 140. Epub 2011 Sep 7por
dc.identifier.otherdoi/10.1111/j.1523-5378.2011.00886.x
dc.identifier.urihttp://hdl.handle.net/10400.18/363
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBlackwell Publishing Ltapor
dc.relationPTDC ⁄ SAU-OSM ⁄ 66323 ⁄ 2006por
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1523-5378.2011.00886.x/pdfpor
dc.subjectHelicobacter pyloripor
dc.subjectNutraceuticalspor
dc.subjectInfecções Gastrointestinaispor
dc.titleNutraceuticals: a new therapeutic approach againstpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceDublinpor
oaire.citation.endPage140por
oaire.citation.startPage140por
oaire.citation.titleXXIVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer, September 11–13, 2011por
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor

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