Logo do repositório
 
Publicação

Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study

2025-12-20Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorLange, Berit
dc.contributor.authorBrehm, Thomas Theo
dc.contributor.authorArend, Sandra M.
dc.contributor.authorArias-Guillén, Miguel
dc.contributor.authorBakker, Marleen
dc.contributor.authorBerastegui, Cristina
dc.contributor.authorBabiker, Maaz
dc.contributor.authorCharif, Rawya
dc.contributor.authorDuarte, Raquel
dc.contributor.authorFlick, Holger
dc.contributor.authorHofland, Regina W.
dc.contributor.authorIsmail, Joanna
dc.contributor.authorKniepeiss, Daniela
dc.contributor.authorKrepel, Jessica
dc.contributor.authorKrishnan, Nithya
dc.contributor.authorKuijpers, Dora L.
dc.contributor.authorKunst, Heinke
dc.contributor.authorvan Leth, Frank
dc.contributor.authorLezaic, Visnja
dc.contributor.authorLos-Arcos, Ibai
dc.contributor.authorMachová, Jana
dc.contributor.authorMilburn, Heather
dc.contributor.authorMorais, Sandra A.
dc.contributor.authorKon, Onn Min
dc.contributor.authorOsoro-Suarez, Carmen
dc.contributor.authorPessegueiro Miranda, Helena
dc.contributor.authorPesut, Dragica
dc.contributor.authorRahman, Ananna
dc.contributor.authorReischig, Tomas
dc.contributor.authorSánchez-Montalvá, Adrián
dc.contributor.authorSpohn, Hanna Elisa
dc.contributor.authorStegenga, Merel T.
dc.contributor.authorde Vries, Aiko P. J.
dc.contributor.authorWagner, Dirk
dc.contributor.authorWobser, Rika
dc.contributor.authorLange, Christoph
dc.contributor.authorSester, Martina
dc.date.accessioned2026-02-13T12:16:44Z
dc.date.available2026-02-13T12:16:44Z
dc.date.issued2025-12-20
dc.description.abstractBackground: Solid organ transplant (SOT) recipients face elevated tuberculosis risk, yet optimal prevention strategies in low- to medium-incidence regions remain unclear. Methods: We conducted a multicenter retrospective cohort study of adult SOT recipients transplanted between 2007 and 2012 at 15 European centers, with follow-up through 2018. The primary outcome was microbiologically confirmed post-transplant tuberculosis. Incidence rates were calculated per 100,000 person-years; standardized incidence ratios (SIRs) used World Health Organization country-specific background rates. Cox models assessed risk factors. Results: Among 5805 patients (median age 51; 62.7% male; 73.9% renal transplants), 33.8% were tested for tuberculosis infection and 10.3% received tuberculosis preventive therapy (TPT). Over 33,785 person-years, 23 patients (0.4%) developed tuberculosis (68.0/100,000 person-years). Highest incidence occurred in patients with positive screening but no TPT (233.8/100,000). Incidence was higher in Southern vs. Central Europe (251.9 vs. 28.7/100,000), with pooled SIRs of 12.8 and 3.1, respectively. Tuberculosis risk was elevated among Southern European recipients (HR 22.9) and those with migration history (HR 2.7). Conclusion: Tuberculosis risk is increased in European SOT recipients. Regionally adapted prevention strategies, including targeted screening in low-incidence areas and universal screening in higher-incidence regions, are warranted.eng
dc.description.abstractHighlights: -Tuberculosis incidence in SOT recipients was 68/100,000 person-years across Europe. -Highest incidence in M. tuberculosis infected persons without preventive therapy. -Southern Europe showed 9-fold higher TB incidence than Central Europe. -Most tuberculosis cases occurred more than two years after transplantation. - Findings support region-specific TB screening and prevention strategies.eng
dc.description.sponsorshipRaquel Duarte is supported by Portuguese Funds through FCT-Foundation for Science and Technology, I.P., under the projects UIDB/04750/2020 (DOI identifier: https://doi.org/10.54499/UIDB/04750/2020) and LA/P/0064/2020 (DOI identifier: https://doi.org/10.54499/LA/P/0064/2020). Tomas Reischig is supported by the Charles University Cooperatio Program, research areas “Immunity and Infections” and “Internal Disciplines”. Adrián Sánchez-Montalvá was supported by a postdoctoral grant, “Juan Rodes” (JR18/00022), from Instituto de Salud Carlos III through the Ministry of Economy and Competitiveness, Spain during the conception and implementation of the project. Christoph Lange is supported by the German Center for Infection Research (DZIF) under Grant agreement TTU-TB 02.709 for clinical tuberculosis research.
dc.identifier.citationJ Infect. 2026 Jan;92(1):106668. doi: 10.1016/j.jinf.2025.106668. Epub 2025 Dec 20
dc.identifier.doi10.1016/j.jinf.2025.106668
dc.identifier.eissn1532-2742
dc.identifier.issn0163-4453
dc.identifier.pmid41429410
dc.identifier.urihttp://hdl.handle.net/10400.18/10932
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0163445325002683?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTuberculosis
dc.subjectIGRA
dc.subjectProgression to Tuberculosis
dc.subjectTBnet
dc.subjectTransplantation
dc.subjectInfecções Respiratórias
dc.subjectCuidados de Saúde
dc.titleTuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort studyeng
dc.typejournal article
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0163445325002683-mmc1.docx
dcterms.referenceshttps://ars.els-cdn.com/content/image/1-s2.0-S0163445325002683-mmc2.docx
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.citation.issue1
oaire.citation.startPage106668
oaire.citation.titleJournal of Infection
oaire.citation.volume92
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
TuberculosisinsolidorgantransplantEurope_TBnetcohortstudy_Lange_2026.pdf
Tamanho:
1.4 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

CD - Artigos em revistas internacionais
INSA - Artigos em revistas internacionais