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Insight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomics

2016-08Journal article Restricted access
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dc.contributor.authorBernardo, Carina
dc.contributor.authorCunha, Maria Cláudia
dc.contributor.authorSantos, Júlio Henrique
dc.contributor.authorda Costa, José M Correia
dc.contributor.authorBrindley, Paul J
dc.contributor.authorLopes, Carlos
dc.contributor.authorAmado, Francisco
dc.contributor.authorFerreira, Rita
dc.contributor.authorVitorino, Rui
dc.contributor.authorSantos, Lúcio Lara
dc.date.accessioned2017-03-07T14:55:56Z
dc.date.available2021-09-01T00:30:09Z
dc.date.issued2016-08
dc.description.abstractInfection due to Schistosoma haematobium is carcinogenic. However, the cellular and molecular mechanisms underlying urogenital schistosomiasis (UGS)-induced carcinogenesis have not been well defined. Conceptually, early molecular detection of this phenomenon, through non-invasive procedures, seems feasible and is desirable. Previous analysis of urine collected during UGS suggests that estrogen metabolites, including depurinating adducts, may be useful for this purpose. Here, a new direction was pursued: the identification of molecular pathways and potential biomarkers in S. haematobium-induced bladder cancer by analyzing the proteome profiling of urine samples from UGS patients. GeLC-MS/MS followed by protein-protein interaction analysis indicated oxidative stress and immune defense systems responsible for microbicide activity are the most representative clusters in UGS patients. Proteins involved in immunity, negative regulation of endopeptidase activity, and inflammation were more prevalent in UGS patients with bladder cancer, whereas proteins with roles in renal system process, sensory perception, and gas and oxygen transport were more abundant in subjects with urothelial carcinoma not associated with UGS. These findings highlighted a Th2-type immune response induced by S. haematobium, which seems to be further modulated by tumorigenesis, resulting in high-grade bladder cancer characterized by an inflammatory response and complement activation alternative pathway. These findings established a starting point for the development of multimarker strategies for the early detection of UGS-induced bladder cancer.pt_PT
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology (FCT), European Union, QREN, FEDER, and COMPETE for funding the QOPNA; by iBiMED research unit (project PEst-C/QUI/UI0062/2013, UID/BIM/04501/2013, UID/IC/00051/2013, and COST action BM1305) and PhD fellowship SFRH/BD/80855/2011 (CB); and by the Portuguese Mass Spectrometry Network (RNEM).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTumour Biol. 2016 Aug;37(8):11279-87. doi: 10.1007/s13277-016-4997-y. Epub 2016 Mar 7pt_PT
dc.identifier.doi10.1007/s13277-016-4997-ypt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4542
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlag / International Society of Oncology and BioMarkers (ISOBM)pt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs13277-016-4997-ypt_PT
dc.subjectAdolescentpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectAnimalspt_PT
dc.subjectCarcinoma, Transitional Cellpt_PT
dc.subjectCell Transformation, Neoplasticpt_PT
dc.subjectElectrophoresis, Polyacrylamide Gelpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectProteomicspt_PT
dc.subjectSchistosoma haematobiumpt_PT
dc.subjectSchistosomiasis haematobiapt_PT
dc.subjectSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationpt_PT
dc.subjectUrinary Bladder Neoplasmspt_PT
dc.subjectYoung Adultpt_PT
dc.subjectInfecções Sistémicas e Zoonoses
dc.titleInsight into the molecular basis of Schistosoma haematobium-induced bladder cancer through urine proteomicspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FQUI%2FUI0062%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04501%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FIC%2F00051%2F2013/PT
oaire.citation.endPage11287pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage11279pt_PT
oaire.citation.titleTumor Biologypt_PT
oaire.citation.volume37pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationcefc5003-39e1-47fb-9a4d-188116bfe083
relation.isProjectOfPublication13ab2a58-e77d-47c0-b1dc-a47355106e8d
relation.isProjectOfPublicationd2f5518b-e4a5-47e7-81c7-78761366fa35
relation.isProjectOfPublication.latestForDiscoveryd2f5518b-e4a5-47e7-81c7-78761366fa35

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