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Risk assessment of multiple mycotoxins in infant food consumed by Portuguese children – the contribute of the MYCOMIX project
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Advisor(s)
Abstract(s)
There is a growing concern within public health about mycotoxin involvement in human diseases, namely those related to children. Scarce data are available in the literature concerning the occurrence of multiple mycotoxins in infant food and their combined toxicity, and no data exists in Portugal concerning this issue. In order to contribute to fill this gap, the MycoMix project, funded by the Portuguese Foundation for Science and Technology, gathered a multidisciplinary team aiming at answering several questions: 1) Are Portuguese children exposed daily to one or several mycotoxins through food? 2) Can this co-exposure affect children´s health? and 3) Are there interaction effect between mycotoxins? Within this project, Portuguese children (< 3 years old, n=103) food consumption data were obtained using a 3 days food diary in a pilot study performed at a Primary Health Care Unit. The main declared infant foods were purchased from the Lisbon market along 2014-15 and analyzed by means of HPLC and LC-MS/MS analytical techniques for multiple mycotoxins co-occurrence. Toxicological studies including bioaccessibility and cyto and genotoxic interactions between detected mycotoxins were also performed using in vitro approaches. Preliminary results showed that 96 % of the analyzed breakfast cereals (BC) were contaminated with one to six different mycotoxins in the same sample and children exposure to single mycotoxins present in BC were well below the tolerable daily intake (TDI) although the margin of exposure (MOS) values for multiple mycotoxins were near one. Bioaccessibility values for single mycotoxins ranged between 42-106% for patulin and aflatoxin M1 in cereal based foods and in infant formulae. Cito and genotoxicity studies on the detected mycotoxins provided evidence on the interaction effect between some binary mixtures of mycotoxins. The assessment of all data is expected to contribute to a more accurate risk assessment of multiple mycotoxins in infant foods consumed by Portuguese children, warranting the safety of infant health. Results obtained within MYCOMIX highlight the challenges posed by the occurrence of multiple chemicals co-occurring in foods.
Description
Abstract publicado em: Toxicology Letters. 2015; 238 (2, Suppl.): S117. doi:10.1016/j.toxlet.2015.08.377. Disponível em: http://www.sciencedirect.com/science/article/pii/S0378427415023164
Keywords
Segurança Alimentar Toxicologia Avaliação de Risco Saúde Humana Genotoxicidade Ambiental