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Occupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approaches

2019-02-01Journal article Open access
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dc.contributor.authorViegas, S.
dc.contributor.authorAssunção, R.
dc.contributor.authorMartins, Carla
dc.contributor.authorNunes, Carla
dc.contributor.authorOsteresch, Bernd
dc.contributor.authorTwaruzek, Magdalena
dc.contributor.authorKosicki, Robert
dc.contributor.authorGrajewski, Jan
dc.contributor.authorRibeiro, Edna
dc.contributor.authorViegas, C.
dc.date.accessioned2020-04-28T21:52:45Z
dc.date.available2020-04-28T21:52:45Z
dc.date.issued2019-02-01
dc.descriptionFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30717100/pt_PT
dc.descriptionThe authors are grateful to the swine farms employers and workers that collaborate in this research project. R.A. and C.M. are grateful to INSA and to CESAM (UID/AMB/50017/2013) through national funds (FCT), and the co-funding by the Fundo Europeu de Desenvolvimento Regional (FEDER) (POCI-01-0145-FEDER-00763), within the PT2020 Partnership Agreement and Compete 2020.pt_PT
dc.description.abstractSwine production workers are exposed simultaneously to multiple contaminants. Occupational exposure to aflatoxin B1 (AFB1) in Portuguese swine production farms has already been reported. However, besides AFB1, data regarding fungal contamination showed that exposure to other mycotoxins could be expected in this setting. The present study aimed to characterize the occupational exposure to multiple mycotoxins of swine production workers. To provide a broad view on the burden of contamination by mycotoxins and the workers’ exposure, biological (urine) samples from workers (n = 25) and 38 environmental samples (air samples, n = 23; litter samples, n = 5; feed samples, n = 10) were collected. The mycotoxins biomarkers detected in the urine samples of the workers group were the deoxynivalenol-glucuronic acid conjugate (60%), aflatoxin M1 (16%), enniatin B (4%), citrinin (8%), dihydrocitrinone (12%) and ochratoxin A (80%). Results of the control group followed the same pattern, but in general with a lower number of quantifiable results (<LOQ). Besides air samples, all the other environmental samples collected presented high and diverse contamination, and deoxynivalenol (DON), like in the biomonitoring results, was the most prominent mycotoxin. The results demonstrate that the occupational environment is adding and contributing to the workers’ total exposure to mycotoxins, particularly in the case of DON. This was confirmed by the biomonitoring data and the high contamination found in feed and litter samples. Furthermore, the followed multi-biomarker approach allowed to conclude that workers and general population are exposed to several mycotoxins simultaneously. Moreover, occupational exposure is probably described as being intermittent and with very high concentrations for short durations. This should be reflected in the risk assessment process.pt_PT
dc.description.sponsorshipThis research was funded by Instituto Politécnico de Lisboa, Lisbon, Portugal: Project “Bacterial Bioburden assessment in the context of occupational exposure and animal health of swine productions (IPL/2016/BBIOR_ESTeSL)” and also by FCT—Fundação para Ciência e Tecnologia: Project “EXPOsE – Establishing protocols to assess occupational exposure to microbiota in clinical settings (02/SAICT/2016 – Project nº 23222)”.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxins (Basel). 2019 Feb 1;11(2):78. doi: 10.3390/toxins11020078pt_PT
dc.identifier.doi10.3390/toxins11020078pt_PT
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/10400.18/6545
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6651/11/2/78pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMicotoxinspt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectMycotoxins Mixturept_PT
dc.subjectOccupational Exposurept_PT
dc.subjectSwine Productionpt_PT
dc.subjectMicotoxinaspt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleOccupational Exposure to Mycotoxins in Swine Production: Environmental and Biological Monitoring Approachespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage78pt_PT
oaire.citation.titleToxinspt_PT
oaire.citation.volume11pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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