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Exposure of Portuguese population to aflatoxins: the contribution of human biomonitoring to estimation of burden of disease

2019-09Conference object Restricted access
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dc.contributor.authorMartins, Carla
dc.contributor.authorVidal, Arnau
dc.contributor.authorDe Boevre, M.
dc.contributor.authorDe Saeger, S.
dc.contributor.authorNunes, Carla
dc.contributor.authorTorres, D.
dc.contributor.authorGoios, A.
dc.contributor.authorLopes, C.
dc.contributor.authorAlvito, Paula
dc.contributor.authorAssunção, Ricardo
dc.date.accessioned2020-05-15T18:45:20Z
dc.date.available2020-05-15T18:45:20Z
dc.date.issued2019-09
dc.description.abstractHuman biomonitoring (HBM) is recognized as an important tool to assess the Human exposure to chemicals, contributing to describe trends and patterns of exposure over time and to identify population groups that could be under risk. Natural chemicals as mycotoxins, fungi metabolites that produce toxic effects in humans, are important compounds that could be found in foods usually consumed worldwide in a daily basis. Mycotoxins as aflatoxins (AFTs) are genotoxic, carcinogenic and immunosuppressive compounds. Hepatocellular carcinoma (HCC) is one of their main health toxic effects and is the third leading cause of cancer deaths worldwide. In Portugal, scarce data are available regarding exposure to AFTs and none previous study used HBM data to characterize comprehensively the burden associated to this exposure. In the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 24h-urine samples from 94 participants were analyzed by liquid chromatography–mass spectrometry (LC-MS/MS) for the simultaneous determination of AFTs (B1, B2, G1, G2, M1). A model was developed to estimate the health impact of the exposure of Portuguese population to aflatoxins, estimating the number of cases of HCC and DALYs attributed to AFTs exposure. AFTs were detected in 12.8% (AFB1), 16.0% (AFB2) and 19.1% (AFM1) of the 24h-urine samples. The estimated number of extra cases of HCC attributed to this exposure ranged from 17 to 65 cases/year; the associated DALYs for the Portuguese population ranged from 284 to 1802 years. The present study generated, for the first time and within a HBM study, reliable data on internal exposure to AFTs at individual level for the Portuguese population. These data were crucial to characterize the burden derived from this exposure and to support risk managers to establish preventive policy measures that contribute to ensure the public health protection.pt_PT
dc.description.sponsorshipThis research was performed with the financial support to CESAM (UID/AMB/50017/2019), to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020. This research was also supported by the project MYTOX-SOUTH, Ghent University Global Minds programme. IAN-AF national survey was funded by the EEA Grants Program, Public Health Initiatives (PT06 - 000088SI3)pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6677
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectChemicalspt_PT
dc.subjectHuman Exposurept_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.subjectPortugalpt_PT
dc.titleExposure of Portuguese population to aflatoxins: the contribution of human biomonitoring to estimation of burden of diseasept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.conferencePlaceAveiro, Portugalpt_PT
oaire.citation.title3rd International Conference on Food Contaminants: Challenges on Risk Assessment, 26-27 September 2019pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublication1d7db62a-6440-4ccb-a5cc-c3f76c8585b3
relation.isProjectOfPublication.latestForDiscovery1d7db62a-6440-4ccb-a5cc-c3f76c8585b3

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