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Schistosoma haematobium: identification of new estrogenic molecules with estradiol antagonistic activity and ability to inactivate estrogen receptor in mammalian cells
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Orientador(es)
Resumo(s)
We have previously identified the expression of an estradiol (E2)-related molecule by Schistosoma haematobium
total antigen (Sh). We now show that this molecule has an antagonistic effect of estradiol
in vitro. Our results are consistent with the existence of an estrogenic molecule that antagonizes the
activity of estradiol. We found evidence for this molecule as we identified and characterized by mass
spectrometry new estrogenic molecules previously unknown, present in schistosome worm extracts
and sera of Schistosoma-infected individuals. We also show that Sh is able to interact in vitro with estrogen
receptor (ER), explaining how host endocrine system can favor the establishment of schistosomes.
These findings highlight the exploitation of the host endocrine system by schistosomes and represent
an additional regulatory component of schistosome development that defines a novel paradigm enabling
host–parasite interactions. The identification of these molecules opens new ways for the development of
alternative drugs to treat schistosomiasis.
Descrição
Palavras-chave
Schistosoma haematobium Estradiol Estrogen receptor MCF-7 cells CHO cells Estrogenic molecules Mass spectrometry Infecções Sistémicas e Zoonoses
Contexto Educativo
Citação
Exp Parasitol. 2010 Dec;126(4):526-35. Epub 2010 Jun 12.