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e_LIPID–Characterization of hypercholesterolemia and association with cardiovascular disease in the Portuguese population

2023-10Conference object Restricted access
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dc.contributor.authorChora, Joana Rita
dc.contributor.authorAlves, Ana Catarina
dc.contributor.authorMariano, Cibelle
dc.contributor.authorAntunes, Marília
dc.contributor.authorRato, Quitéria
dc.contributor.authorBourbon, Mafalda
dc.date.accessioned2024-01-24T15:53:08Z
dc.date.available2024-01-24T15:53:08Z
dc.date.issued2023-10
dc.description.abstractThe e_LIPID study aimed to characterise the lipid profile of the Portuguese population and study its association with cardiovascular disease (CV D) events. Demographic, clinical, and biochemical data derived from the e_COR Study, a cross-sectional epidemiological study with 1688 adults (18-79 years old) from five Portuguese continental regions. Population specific percentiles for lipid and lipoprotein biomarkers were es􀀚mated stratified by sex and age. All calculations were weighted by sex, age, and geographic region to be representative of the mainland Portuguese population. Odds ratio was calculated to study association of biochemical profile with CV D. Associations of total cholesterol (TC), LDL, ApoB and non-HDL were performed only on individuals under no lipid-lowering therapy. Individuals with LDL above the 9th5 percentile and fulfilling Simon-Broome criteria of Familial Hypercholesterolemia (FH) were sequenced for LDLR, APOB and PCSK9. National prevalence of individuals with TC≥190mg/dl were 52.4%, with LDL≥116mg/dl were 53.9%, with ApoB≥90mg/dl were 53.8%, with non- HDL≥146mg/dl were 38.9%, and with Lp(a)≥125nmol/L were 21.1%. The 90th percentile for lipid and lipoprotein biomarkers for the Portuguese population are TC of 244mg/dl, LDL of 169mg/dl, ApoB of 128mg/dl, non-HDL of 193mg/dl, and Lp(a) of 223nmol/L. The 10th percentile for HDL is 38mg/dl. Individuals with LDL≥116mg/dl presented 2.50 [1.13-6.07] higher odds of having had CV D events (p=0.018), with non-HDL≥146mg/dl had 2.06 [1.01-4.31] higher odds (p=0.041), and with high Lp(a)≥125nmol/L had 1.77 [1.13-2.72] higher odds (p=0.008) than their respective counterparts. From the 33 individuals sequenced 3 individuals were found to have heterozygous FH. Population age and sex specific values are important for dyslipidaemia assessment. Having LDL≥116mg/dl, non-HDL≥146mg/dl or Lp(a) ≥125nmol/L can double the odds of CV D. Our results highlight that hypercholesterolemia is a neglected cardiovascular risk factor with more than 50% of the population with TC≥190mg/dl, LDL≥116mg/dl, or ApoB≥90mg/dl. Since hypercholesterolemia is a modifiable risk factor in the majority of cases, strategies to increase adherence to changes in lifestyle habits need to be urgently discussed.pt_PT
dc.description.sponsorshipFCTpt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8969
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.subjectBiochemical Profilept_PT
dc.subjectCardiovascular Diseasept_PT
dc.subjectRisk Factorspt_PT
dc.subjectHypercholesterolemiapt_PT
dc.subjectDoenças Cardio e Cérebro-vascularespt_PT
dc.subjectPortugal
dc.titlee_LIPID–Characterization of hypercholesterolemia and association with cardiovascular disease in the Portuguese populationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePeniche, Portugalpt_PT
oaire.citation.titleXXXI Congresso Português de Aterosclerose (CPA), 27-28 outubro 2023pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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