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European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?

2019-02-18Journal article Restricted access
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dc.contributor.authorNielsen, Jens
dc.contributor.authorVestergaard, Lasse
dc.contributor.authorRichter, L.
dc.contributor.authorSchmid, D.
dc.contributor.authorBustos, N.
dc.contributor.authorAsikainen, T.
dc.contributor.authorTrebbien, R.
dc.contributor.authorDenissov, G.
dc.contributor.authorInnos, K.
dc.contributor.authorVirtanen, M.J.
dc.contributor.authorFouillet, A.
dc.contributor.authorLytras, T.
dc.contributor.authorGkolfinopoulou, K.
dc.contributor.authorHeiden, M. an der
dc.contributor.authorGrabenhenrich, L.
dc.contributor.authorUphoff, H.
dc.contributor.authorPaldy, A.
dc.contributor.authorBobvos, J.
dc.contributor.authorDomegan, L.
dc.contributor.authorO'Donnell, J.
dc.contributor.authorScortichini, M.
dc.contributor.authorde Martino, A.
dc.contributor.authorMossong, J.
dc.contributor.authorEngland, K.
dc.contributor.authorMelillo, J.
dc.contributor.authorvan Asten, L.
dc.contributor.authorde Lange, M. MA
dc.contributor.authorTønnessen, R.
dc.contributor.authorWhite, R.A.
dc.contributor.authorSilva, Susana Pereira
dc.contributor.authorRodrigues, Ana Paula
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorMazagatos, Clara
dc.contributor.authorFarah, A.
dc.contributor.authorCarnahan, A.D.
dc.contributor.authorJunker, C.
dc.contributor.authorSinnathamby, M.
dc.contributor.authorPebody, R.G.
dc.contributor.authorAndrews, N.
dc.contributor.authorReynolds, A.
dc.contributor.authorMcMenamin, J.
dc.contributor.authorBrown, C.S.
dc.contributor.authorAdlhoch, C.
dc.contributor.authorPenttinen, P.
dc.contributor.authorMølbak, K.
dc.contributor.authorKrause, T.G.
dc.date.accessioned2020-04-23T16:37:35Z
dc.date.available2020-04-23T16:37:35Z
dc.date.issued2019-02-18
dc.description.abstractObjectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Microbiol Infect. 2019 Oct;25(10):1266-1276. doi: 10.1016/j.cmi.2019.02.011. Epub 2019 Feb 18pt_PT
dc.identifier.doi10.1016/j.cmi.2019.02.011pt_PT
dc.identifier.issn1198-743X
dc.identifier.urihttp://hdl.handle.net/10400.18/6499
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ on behalf of European Society of Clinical Microbiology and Infectious Diseasespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1198743X19300588?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectMortalitypt_PT
dc.subjectVDMpt_PT
dc.subjectB/Yamagatapt_PT
dc.subjectB/Yamagatapt_PT
dc.subjectEuroMOMOpt_PT
dc.subjectFluMOMOpt_PT
dc.subjectInfluenzapt_PT
dc.subjectMortalitypt_PT
dc.subjectMortalidadept_PT
dc.subjectEuroMOMOpt_PT
dc.subjectFluMOMOpt_PT
dc.subjectInfluenzapt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleEuropean all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1276pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1266pt_PT
oaire.citation.titleClinical Microbiology and Infectionpt_PT
oaire.citation.volume25pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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