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Impact of occupational exposure to wildfire events on systemic inflammatory biomarkers in Portuguese wildland firefighters

2025-04-14Artigo científico Acesso aberto
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dc.contributor.authorEsteves, Filipa
dc.contributor.authorMadureira, Joana
dc.contributor.authorBarros, Bela
dc.contributor.authorAlves, Sara
dc.contributor.authorPires, Joana
dc.contributor.authorMartins, Sandra
dc.contributor.authorOliveira, Marta
dc.contributor.authorVaz, Josiana
dc.contributor.authorSlezakova, Klara
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorFernandes, Adília
dc.contributor.authorMorais, Simone
dc.contributor.authorGuimarães, João Tiago
dc.contributor.authorBonassi, Stefano
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCosta, Solange
dc.date.accessioned2026-02-20T16:08:15Z
dc.date.available2026-02-20T16:08:15Z
dc.date.issued2025-04-14
dc.description.abstractWhile occupational exposure as a firefighter is considered a dangerous occupation, research on the underlying mechanisms remains limited, particularly in wildland firefighters. Inflammation, a key effect of wildfire exposure, plays a significant role in the development of various diseases. The current study aims to investigate the impact of wildland firefighting exposure on the levels of pro-inflammatory systemic biomarkers. A pre-post study design investigated 59 wildland firefighters comparing data collected after participation in a wildfire event (Phase II) with data obtained before wildfire season (Phase I). Data on demographics, lifestyle, health and occupational-related factors were assessed. Exposure factors, such as fire combat (e.g., exposure duration), were also registered. Inflammatory biomarkers (i.e. interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor α [TNF-α] and high-sensitivity C-reactive protein [hs-CRP]) and hydroxylated polycyclic aromatic hydrocarbons metabolites (1-OHNaph+1-OHAce, 2-OHFlu, 1-OHPhen, 1-OHPyr) were analysed in blood and urine samples, respectively. Serum IL-8 and IL-6 levels were significantly increased after wildland fire combat. IL-8 levels were 2.62 times higher (95 % CI: 1.96-3.50; p < 0.01), whereas IL-6 levels were 1.25 times higher (95 % CI: 1.00-1.57; p = 0.04). Furthermore, IL-8 levels were significantly correlated with urinary 2-hydroxyfluorene levels and fire combat duration (>12 h). In addition, the mean hs-CRP level, in both phases, was above 3.0 mg/L, indicating a potential risk for cardiovascular events. Given the long-term health implications of firefighting occupational exposure, biomonitoring and early detection of occupational risks are essential for protecting firefighters' health. Protective measures must be urgently implemented to enhance occupational health and strengthen preventive strategies in this sector.eng
dc.description.abstractHighlights: - Serum IL-8 levels increased 2.62 times post-wildfire combat. - Firefighters combating over 12 h exhibited higher IL-8 levels. - Serum IL-6 levels were 1.25 times higher after wildland firefighting. - Elevated serum IL-8 correlated with urinary 2-hydroxyfluorene levels. - High hs-CRP levels indicate increased cardiovascular disease risk.eng
dc.description.sponsorshipThis work received financial support from the project PCIF/SSO/0017/2018 (https://doi.org/10.54499/PCIF/SSO/0017/2018) by the Fundação para a Ciência e a Tecnologia (FCT), Ministério da Ciência, Tecnologia e Ensino Superior (MCTES), through national funds. This work is financed by national funds through the FCT within the scope of projects UIDB/04750/2020 (https://doi.org/10.54499/UIDB/04750/2020) and LA/P/0064/2020 (https://doi.org/10.54499/LA/P/0064/2020). Filipa Esteves was supported by National Funds through FCT, under the Ph.D. fellowship UI/BD/150783/2020. The work of Stefano Bonassi was supported by the Italian Ministry of Health (Ricerca Corrente), Rome, Italy, and by the Competitive Funding for University Research Projects [Finanziamento competitivo di progetti di ricerca di ateneo (FIN/RIC)] San Raffaele University, Rome, Italy.
dc.identifier.citationEnviron Res. 2025 Jul 15:277:121608. doi: 10.1016/j.envres.2025.121608. Epub 2025 Apr 14
dc.identifier.doi10.1016/j.envres.2025.121608
dc.identifier.issn0013-9351
dc.identifier.pmid40233845
dc.identifier.urihttp://hdl.handle.net/10400.18/10974
dc.language.isoen
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationLaboratory for Integrative and Translational Research in Population Health
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S001393512500859X?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiomarkers
dc.subjectCytokines
dc.subjectFirefighting
dc.subjectInflammation
dc.subjectWildland Firefighters
dc.subjectWoodsmoke Exposure
dc.subjectGenotoxicidade Ambiental
dc.subjectAr e Saúde Ocupacional
dc.titleImpact of occupational exposure to wildfire events on systemic inflammatory biomarkers in Portuguese wildland firefighterspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleLaboratory for Integrative and Translational Research in Population Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0064%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/UI%2FBD%2F150783%2F2020/PT
oaire.citation.startPage121608
oaire.citation.titleEnvironmental Research
oaire.citation.volume277
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isProjectOfPublication05f4f337-eeba-4c07-82ed-4202b21618a2
relation.isProjectOfPublication18ca3cb0-ef66-4dd8-b45e-4cb0654cd7e8
relation.isProjectOfPublicationc67e4748-32c2-442b-8b64-0748a80fefe8
relation.isProjectOfPublication.latestForDiscovery05f4f337-eeba-4c07-82ed-4202b21618a2

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