The Application and Interpretation of IgG Avidity and IgA ELISA Tests to Characterize Zika Virus Infections

In the absence of viremia, the diagnostics of Zika virus (ZIKV) infections must rely on serologicaltechniques. InordertoimprovetheserologicaldiagnosisofZIKV,ZIKV-IgAandZIKV-IgG avidity assays were evaluated. Forty patients returning from ZIKV endemic areas, with conﬁrmed or suspected ZIKV infections were studied. Samples were classiﬁed as early acute, acute and late acute according to the number of days post illness onset. Low avidity IgG was only detected at acute and late acute stages and IgA mostly at the early acute and acute stages. The date of sampling provides useful information and can help to choose the best technique to use at a determined moment in time and to interpret low avidity IgG and IgA results, improving the serological diagnosis of ZIKV.

Keywords

Zika Virus Dengue Virus Secondary Infections Cross-reactions IgA IgG Avidity Tests Infecções Sistémicas e Zoonoses

URI

http://hdl.handle.net/10400.18/6562

Citation

Viruses. 2019 Feb 20;11(2):179. doi: 10.3390/v11020179

Publisher

MDPI

DOI

10.3390/v11020179

Collections

DDI - Artigos em revistas internacionais

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