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Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs

2015-09-21Journal article Open access
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dc.contributor.authorNeves, F.
dc.contributor.authorAbrantes, J.
dc.contributor.authorAlmeida, T.
dc.contributor.authorde Matos, A.L.
dc.contributor.authorCosta, Paulo
dc.contributor.authorEsteves, P.J.
dc.date.accessioned2016-02-12T16:44:44Z
dc.date.available2016-02-12T16:44:44Z
dc.date.issued2015-09-21
dc.descriptionDisponível em: www.ncbi.nlm.nih.gov/pmc/articles/pmid/26395994/pt_PT
dc.description.abstractILs, as essential innate immune modulators, are involved in an array of biological processes. In the European rabbit (Oryctolagus cuniculus) IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18 have been implicated in inflammatory processes and in the immune response against rabbit hemorrhagic disease virus and myxoma virus infections. In this study we characterized these ILs in six Lagomorpha species (European rabbit, pygmy rabbit, two cottontail rabbit species, European brown hare and American pika). Overall, these ILs are conserved between lagomorphs, including in their exon/intron structure. Most differences were observed between leporids and American pika. Indeed, when comparing both, some relevant differences were observed in American pika, such as the location of the stop codon in IL-1α and IL-2, the existence of a different transcript in IL8 and the number of cysteine residues in IL-1β. Changes at N-glycosylation motifs were also detected in IL-1, IL-10, IL-12B and IL-15. IL-1α is the protein that presents the highest evolutionary distances, which is in contrast to IL-12A where the distances between lagomorphs are the lowest. For all these ILs, sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse.pt_PT
dc.description.abstractResearch Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::ImmunologyResearch Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Geneticspt_PT
dc.description.sponsorshipFCT and North Portugal Regional Operational Programme 2007/2013 (ON.2) grants supported this work.pt_PT
dc.identifier.citationInnate Immun. 2015 Nov;21(8):787-801. doi: 10.1177/1753425915606209. Epub 2015 Sep 21pt_PT
dc.identifier.doi10.1177/1753425915606209pt_PT
dc.identifier.issn1753-4259
dc.identifier.urihttp://hdl.handle.net/10400.18/3284
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInternational Endotoxin and Innate Immunity Societypt_PT
dc.relation.publisherversionhttp://ini.sagepub.com/cgi/pmidlookup?view=long&pmid=26395994pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectImmune Systempt_PT
dc.subjectInterleukinspt_PT
dc.subjectRabbitpt_PT
dc.subjectLagomorphapt_PT
dc.subjectDoenças Genéticaspt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleGenetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage801pt_PT
oaire.citation.startPage787pt_PT
oaire.citation.titleInnate Immunitypt_PT
oaire.citation.volume21(8)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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