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Ambient particulate air pollution and daily mortality in 652 cities

2019-08-22Journal article Restricted access
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dc.contributor.authorLiu, Cong
dc.contributor.authorChen, Renjie
dc.contributor.authorSera, Francesco
dc.contributor.authorVicedo-Cabrera, Ana M.
dc.contributor.authorGuo, Yuming
dc.contributor.authorTong, Shilu
dc.contributor.authorCoelho, Micheline S.Z.S.
dc.contributor.authorSaldiva, Paulo H.N.
dc.contributor.authorLavigne, Eric
dc.contributor.authorMatus, Patricia
dc.contributor.authorValdes Ortega, Nicolas
dc.contributor.authorOsorio Garcia, Samuel
dc.contributor.authorPascal, Mathilde
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorScortichini, Matteo
dc.contributor.authorHashizume, Masahiro
dc.contributor.authorHonda, Yasushi
dc.contributor.authorHurtado-Díaz, Magali
dc.contributor.authorCruz, Julio
dc.contributor.authorNunes, Baltazar
dc.contributor.authorTeixeira, João P.
dc.contributor.authorKim, Ho
dc.contributor.authorTobias, Aurelio
dc.contributor.authorÍñiguez, Carmen
dc.contributor.authorForsberg, Bertil
dc.contributor.authorÅström, Christofer
dc.contributor.authorRagettli, Martina S.
dc.contributor.authorGuo, Yue-Leon
dc.contributor.authorChen, Bing-Yu
dc.contributor.authorBell, Michelle L.
dc.contributor.authorWright, Caradee Y.
dc.contributor.authorScovronick, Noah
dc.contributor.authorGarland, Rebecca M.
dc.contributor.authorMilojevic, Ai
dc.contributor.authorKyselý, Jan
dc.contributor.authorUrban, Aleš
dc.contributor.authorOrru, Hans
dc.contributor.authorIndermitte, Ene
dc.contributor.authorJaakkola, Jouni J.K.
dc.contributor.authorRyti, Niilo R.I.
dc.contributor.authorKatsouyanni, Klea
dc.contributor.authorAnalitis, Antonis
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorSchwartz, Joel
dc.contributor.authorChen, Jianmin
dc.contributor.authorWu, Tangchun
dc.contributor.authorCohen, Aaron
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorKan, Haidong
dc.date.accessioned2020-04-21T16:07:08Z
dc.date.available2020-08-22T00:30:14Z
dc.date.issued2019-08-22
dc.description.abstractThe systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. We evaluated the associations of inhalable particulate matter (PM) with an aerodynamic diameter of 10 μm or less (PM10) and fine PM with an aerodynamic diameter of 2.5 μm or less (PM2.5) with daily all-cause, cardiovascular, and respiratory mortality across multiple countries or regions. Daily data on mortality and air pollution were collected from 652 cities in 24 countries or regions. We used overdispersed generalized additive models with random-effects meta-analysis to investigate the associations. Two-pollutant models were fitted to test the robustness of the associations. Concentration-response curves from each city were pooled to allow global estimates to be derived. On average, an increase of 10 μg per cubic meter in the 2-day moving average of PM10 concentration, which represents the average over the current and previous day, was associated with increases of 0.44% (95% confidence interval [CI], 0.39 to 0.50) in daily all-cause mortality, 0.36% (95% CI, 0.30 to 0.43) in daily cardiovascular mortality, and 0.47% (95% CI, 0.35 to 0.58) in daily respiratory mortality. The corresponding increases in daily mortality for the same change in PM2.5 concentration were 0.68% (95% CI, 0.59 to 0.77), 0.55% (95% CI, 0.45 to 0.66), and 0.74% (95% CI, 0.53 to 0.95). These associations remained significant after adjustment for gaseous pollutants. Associations were stronger in locations with lower annual mean PM concentrations and higher annual mean temperatures. The pooled concentration-response curves showed a consistent increase in daily mortality with increasing PM concentration, with steeper slopes at lower PM concentrations. Our data show independent associations between short-term exposure to PM10 and PM2.5 and daily all-cause, cardiovascular, and respiratory mortality in more than 600 cities across the globe. These data reinforce the evidence of a link between mortality and PM concentration established in regional and local studies. (Funded by the National Natural Science Foundation of China and others).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationN Engl J Med. 2019 Aug 22;381(8):705-715. doi: 10.1056/NEJMoa1817364pt_PT
dc.identifier.doi10.1056/NEJMoa1817364pt_PT
dc.identifier.issn0028-4793
dc.identifier.urihttp://hdl.handle.net/10400.18/6470
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMassachusetts Medical Societypt_PT
dc.relation.publisherversionhttps://www.nejm.org/doi/full/10.1056/NEJMoa1817364pt_PT
dc.subjectAir Pollutionpt_PT
dc.subjectCardiovascular Diseasespt_PT
dc.subjectCause of Deathpt_PT
dc.subjectEnvironmental Exposurept_PT
dc.subjectGlobal Healthpt_PT
dc.subjectHumanspt_PT
dc.subjectParticle Sizept_PT
dc.subjectParticulate Matterpt_PT
dc.subjectRespiratory Tract Diseasespt_PT
dc.subjectRiskpt_PT
dc.subjectMortalitypt_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleAmbient particulate air pollution and daily mortality in 652 citiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage715pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage705pt_PT
oaire.citation.titleNew England Journal of Medicinept_PT
oaire.citation.volume381pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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