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Analysis of shared heritability in common disorders of the brain

2018-01-22Artigo científico Acesso restrito
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dc.contributor.authorAnttila, Verneri
dc.contributor.authorBulik-Sullivan, Brendan
dc.contributor.authorFinucane, Hilary K.
dc.contributor.authorWalters, Raymond K.
dc.contributor.authorBras, Jose
dc.contributor.authorDuncan, Laramie
dc.contributor.authorEscott-Price, Valentina
dc.contributor.authorFalcone, Guido J.
dc.contributor.authorGormley, Padhraig
dc.contributor.authorMalik, Rainer
dc.contributor.authorPatsopoulos, Nikolaos A.
dc.contributor.authorSchoch, Susanne
dc.contributor.authorSisodiya, Sanjay M.
dc.contributor.authorSmith, Philip
dc.contributor.authorSperling, Michael
dc.contributor.authorStriano, Pasquale
dc.contributor.authorSurges, Rainer
dc.contributor.authorThomas, G. Neil
dc.contributor.authorVisscher, Frank
dc.contributor.authorWhelan, Christopher D.
dc.contributor.authorBerr, Claudine
dc.contributor.authorKurth, Tobias
dc.contributor.authorZara, Federico
dc.contributor.authorHeinzen, Erin L.
dc.contributor.authorMarson, Anthony
dc.contributor.authorBecker, Felicitas
dc.contributor.authorStroink, Hans
dc.contributor.authorZimprich, Fritz
dc.contributor.authorGasser, Thomas
dc.contributor.authorGibbs, Raphael
dc.contributor.authorHeutink, Peter
dc.contributor.authorMartinez, Maria
dc.contributor.authorLigthart, Lannie
dc.contributor.authorLetenneur, Luc
dc.contributor.authorMorris, Huw R.
dc.contributor.authorSharma, Manu
dc.contributor.authorRyten, Mina
dc.contributor.authorMok, Kin Y.
dc.contributor.authorPulit, Sara
dc.contributor.authorBevan, Steve
dc.contributor.authorHolliday, Elizabeth
dc.contributor.authorAttia, John
dc.contributor.authorBattey, Thomas
dc.contributor.authorTerwindt, Gisela M.
dc.contributor.authorBoncoraglio, Giorgio
dc.contributor.authorHannequin, Didier
dc.contributor.authorThijs, Vincent
dc.contributor.authorChen, Wei-Min
dc.contributor.authorMitchell, Braxton
dc.contributor.authorRothwell, Peter
dc.contributor.authorSharma, Pankaj
dc.contributor.authorSudlow, Cathie
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dc.contributor.authorAmouyel, Philippe
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dc.contributor.authorWilliam Rayner, N.
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dc.contributor.authorSchankin, Christoph
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorScheffer, Ingrid
dc.date.accessioned2018-07-27T17:13:25Z
dc.date.available2020-01-01T01:30:15Z
dc.date.issued2018-01-22
dc.descriptionAstrid Vicente (INSA), member of The Brainstorm Consortium.pt_PT
dc.description.abstractDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationScience. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757pt_PT
dc.identifier.doi10.1126/science.aap8757pt_PT
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/10400.18/5596
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relation.publisherversionhttp://science.sciencemag.org/content/360/6395/eaap8757.longpt_PT
dc.subjectBrainpt_PT
dc.subjectDisorders of the Brainpt_PT
dc.subjectPsychiatric Genomicspt_PT
dc.subjectGenetic Factorspt_PT
dc.subjectPsychiatric Disorderspt_PT
dc.subjectNeurological Disorderspt_PT
dc.subjectRisks factorspt_PT
dc.subjectEtiologypt_PT
dc.subjectPerturbações do Desenvolvimento Infantil e Saúde Mental
dc.titleAnalysis of shared heritability in common disorders of the brainpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6395pt_PT
oaire.citation.startPageeaap8757pt_PT
oaire.citation.titleSciencept_PT
oaire.citation.volume360pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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