Repository logo
 
Publication

Paper 4: EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe

2011-03-04Journal article Restricted access
Simple item page
dc.contributor.authorLoane, Maria
dc.contributor.authorDolk, Helen
dc.contributor.authorKelly, Alan
dc.contributor.authorTeljeur, Conor
dc.contributor.authorGreenlees, Ruth
dc.contributor.authorDensem, James
dc.contributor.authorEUROCAT Working Group
dc.date.accessioned2012-02-15T13:20:12Z
dc.date.available2012-02-15T13:20:12Z
dc.date.issued2011-03-04
dc.descriptionEUROCAT Working group collaborator: Carlos Diaspor
dc.description.abstractAs part of EUROCAT’s surveillance of congenital anomalies in Europe, a statistical monitoring system has been developed to detect recent clusters or long-term (10 year) time trends. The purpose of this article is to describe the system for the identification and investigation of 10-year time trends, conceived as a ‘‘screening’’ tool ultimately leading to the identification of trends which may be due to changing teratogenic factors. METHODS: The EUROCAT database consists of all cases of congenital anomalies including livebirths, fetal deaths from 20 weeks gestational age, and terminations of pregnancy for fetal anomaly. Monitoring of 10-year trends is performed for each registry for each of 96 non-independent EUROCAT congenital anomaly subgroups, while Pan-Europe analysis combines data from all registries. The monitoring results are reviewed, prioritized according to a prioritization strategy, and communicated to registries for investigation. Twenty-one registries covering over 4 million births, from 1999 to 2008, were included in monitoring in 2010. CONCLUSIONS: Significant increasing trends were detected for abdominal wall anomalies, gastroschisis, hypospadias, Trisomy 18 and renal dysplasia in the Pan-Europe analysis while 68 increasing trends were identified in individual registries. A decreasing trend was detected in over one-third of anomaly subgroups in the Pan-Europe analysis, and 16.9% of individual registry tests. Registry preliminary investigations indicated that many trends are due to changes in data quality, ascertainment, screening, or diagnostic methods. Some trends are inevitably chance phenomena related to multiple testing, while others seem to represent real and continuing change needing further investigation and response by regional/national public health authorities.por
dc.identifier.citationBirth Defects Res A Clin Mol Teratol. 2011 Mar;91 Suppl 1:S31-43. Epub 2011 Mar 4por
dc.identifier.issn1542-0752
dc.identifier.otherdoi: 10.1002/bdra.20778
dc.identifier.urihttp://hdl.handle.net/10400.18/565
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley-Lisspor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/bdra.20778/abstract;jsessionid=7381672AC9545033A37EEC47A3CA886C.d01t03por
dc.subjectCongenital Anomaliespor
dc.subjectMonitoringpor
dc.subjectTrendspor
dc.subjectPrevalencepor
dc.subjectEstados de Saúde e de Doençapor
dc.subjectRENACpor
dc.titlePaper 4: EUROCAT statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageS43por
oaire.citation.startPageS31por
oaire.citation.titleBirth Defects Research Part A: Clinical and Molecular Teratologypor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Paper 4 - EUROCAT Statistical Monitoring - Identification of ten year trends of congenital anomalies in Europe.pdf
Size:
1.35 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DEP - Artigos em revistas internacionais