Integrative network approach to predict new NMD-associated proteins

Nogueira, Gonçalo; Romão, Luísa; Pinto, Francisco

http://hdl.handle.net/10400.18/6004

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Authors

Nogueira, Gonçalo

Romão, Luísa

Pinto, Francisco

Abstract(s)

In our study, we apply such approach to predict new players involved in nonsense-mediated mRNA decay (NMD), a regulatory pathway of mRNA translation that recognizes and selectively degrades specific mRNAs. NMD is a complex process that relies on the involvement of numerous players, however the interactions and connectivity among these components is only partly elucidated.