Publication
Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection
| dc.contributor.author | Cardoso, R. | |
| dc.contributor.author | Lacerda, P.C. | |
| dc.contributor.author | Costa, P.P. | |
| dc.contributor.author | Machado, A. | |
| dc.contributor.author | Carvalho, A. | |
| dc.contributor.author | Bordalo, A. | |
| dc.contributor.author | Fernandes, R. | |
| dc.contributor.author | Soares, R. | |
| dc.contributor.author | Richter, J. | |
| dc.contributor.author | Alves, H. | |
| dc.contributor.author | Botelho, M.C. | |
| dc.date.accessioned | 2018-03-05T16:59:05Z | |
| dc.date.available | 2018-03-05T16:59:05Z | |
| dc.date.issued | 2017-11-28 | |
| dc.description.abstract | Schistosoma haematobium is a human blood fluke causing a chronic infection called urogenital schistosomiasis. Squamous cell carcinoma of the urinary bladder (SCC) constitutes chronic sequelae of this infection, and S. haematobium infection is accounted as a risk factor for this type of cancer. This infection is considered a neglected tropical disease and is endemic in numerous countries in Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These estrogenic molecules are metabolized to active quinones that induce modifications in DNA. The cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases involved in estrogen biosynthesis and metabolism, the generation of DNA damaging procarcinogens, and the response to anti-estrogen therapies. IL6 Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in various tissues. This cytokine is largely expressed in the female urogenital tract as well as reproductive organs. Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance. In the present study, we investigated the polymorphic variants in the CYP2D6 gene and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium-infected children patients from Guine Bissau. CYP2D6 inactivated alleles (28.5%) and IL6G-174C (13.3%) variants were frequent in S. haematobium-infected patients when compared to previously studied healthy populations (4.5% and 0.05%, respectively). Here we discuss our recent findings on these polymorphisms and whether they can be predictive markers of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility. | pt_PT |
| dc.description.sponsorship | This work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274), and by UID/BIM/04293/2013. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Int J Mol Sci. 2017 Nov 28;18(12). pii: E2560. doi: 10.3390/ijms18122560. | pt_PT |
| dc.identifier.doi | 10.3390/ijms18122560 | pt_PT |
| dc.identifier.issn | 1661-6596 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5173 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | pt_PT |
| dc.relation.publisherversion | http://www.mdpi.com/1422-0067/18/12/2560 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | BMI | pt_PT |
| dc.subject | S. haematobium-associated Bladder Cancer | pt_PT |
| dc.subject | Schistosoma Haematobium Infection | pt_PT |
| dc.subject | Estrogen Biosynthesis | pt_PT |
| dc.subject | Estrogen Metabolism | pt_PT |
| dc.title | Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04293%2F2013/PT | |
| oaire.citation.conferencePlace | Basel, Switzerland | pt_PT |
| oaire.citation.issue | 12 | pt_PT |
| oaire.citation.startPage | pii: E2560 | pt_PT |
| oaire.citation.title | International Journal of Molecular Sciences | pt_PT |
| oaire.citation.volume | 18 | pt_PT |
| oaire.fundingStream | 5876 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | fa9009ed-65e1-4108-bd20-1304211124ea | |
| relation.isProjectOfPublication.latestForDiscovery | fa9009ed-65e1-4108-bd20-1304211124ea |