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Insights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in greater Lisbon, Portugal: Implications at the public health level

2019-03-27Journal article Restricted access
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dc.contributor.authorPereira, Catarina
dc.contributor.authorGomes, Pedro
dc.contributor.authorTaveira, Ricardo
dc.contributor.authorSilva, Carla
dc.contributor.authorMaltez, Fernando
dc.contributor.authorMacedo, Rita
dc.contributor.authorCosta, Catarina
dc.contributor.authorCouvin, David
dc.contributor.authorRastogi, Nalin
dc.contributor.authorViveiros, Miguel
dc.contributor.authorPerdigão, João
dc.contributor.authorPortugal, Isabel
dc.date.accessioned2019-04-01T15:04:00Z
dc.date.available2022-01-01T01:30:11Z
dc.date.issued2019-03-27
dc.description.abstractTuberculosis among foreign-born patients is a key indicator of country-level epidemiological profiles and, of an increasing concern in Europe given the more intensified migratory waves of refugees. Since Portugal presents a lower immigrant-associated TB incidence rate when compared to other European countries, we sought to characterize the epidemiology and transmission dynamics among the foreign-born population coming from Portuguese-speaking countries that are associated with higher TB incidences. In the present study we analyzed 133 Mycobacterium tuberculosis isolates obtained from foreign-born individuals over a three-year period in Lisbon, Portugal, using molecular epidemiological methods such as spoligotyping and 24-loci MIRU-VNTR. Moreover, all strains were subjected to drug susceptibility testing. The genetic profiles obtained suggest that strain importation from Portuguese speaking countries plays a less important role in TB epidemiology but instead argue in favor of a high degree of penetrance of Portuguese endemic strains to the migrant population, including multidrug resistant strains, which is particularly relevant to active screening programs.pt_PT
dc.description.sponsorshipFinancial support was provided by the European Society of Clinical Microbiology and Infectious Diseases, for which we would like to would like to acknowledge the Study Group for Mycobacterial Infections;JP was supported by a post doc fellowship [SFRH/BPD/95406/2013] from FCT. The phylogenetic analysis work at Nalin Rastogi's lab was supported by a FEDER grant financed by the European Union and Guadeloupe Region (Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020, Grant number 2015-FED-192).MV is thankful to [GHTM UID/Multi/04413/2013] from FCT and toprojects “ForDILAB-TB” and “A implementação de um novo método de identificação rápida do complexo M. tuberculosis nos Laboratórios de Referência da Tuberculose de Maputo e Beira” from Fundação Calouste Gulbenkian and the Community of the Portuguese Speaking Countries (CPLP), as well as toour colleagues Ana Tavares and Sonia Dias for their valuable contribution with the epidemiological and health-care services provided to migrants in Portugal related aspects. CS was supported by FCT [SFRH/BD/73579/2010].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInfect Genet Evol. 2019 Jul;71:159-165. doi: 10.1016/j.meegid.2019.03.025. Epub 2019 Mar 27pt_PT
dc.identifier.doi10.1016/j.meegid.2019.03.025pt_PT
dc.identifier.issn1567-1348
dc.identifier.urihttp://hdl.handle.net/10400.18/6351
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1567134819300462?via%3Dihubpt_PT
dc.subjectTuberculosispt_PT
dc.subjectM. Tuberculosispt_PT
dc.subjectMycobacterium tuberculosispt_PT
dc.subjectLisbonpt_PT
dc.subjectPortugalpt_PT
dc.subjectMIRU-VNTRpt_PT
dc.subjectMigrantspt_PT
dc.subjectRDRiopt_PT
dc.subjectSpoligotypingpt_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titleInsights on the Mycobacterium tuberculosis population structure associated with migrants from Portuguese-speaking countries over a three-year period in greater Lisbon, Portugal: Implications at the public health levelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73579%2F2010/PT
oaire.citation.endPage165
oaire.citation.startPage159
oaire.citation.titleInfection, Genetics and Evolutionpt_PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationad39241e-5511-4aa7-975d-680cd5082c36
relation.isProjectOfPublication2f8be117-2e10-4c8f-93f5-c79254ecb712
relation.isProjectOfPublication.latestForDiscoveryad39241e-5511-4aa7-975d-680cd5082c36

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