Repository logo
 
Publication

Short-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Cities

2023-03-08Journal article Open access
Simple item page
dc.contributor.authorO’Brien, Edward
dc.contributor.authorMasselot, Pierre
dc.contributor.authorSera, Francesco
dc.contributor.authorRoye, Dominic
dc.contributor.authorBreitner, Susanne
dc.contributor.authorNg, Chris Fook Sheng
dc.contributor.authorde Sousa Zanotti Stagliorio Coelho, Micheline
dc.contributor.authorMadureira, Joana
dc.contributor.authorTobias, Aurelio
dc.contributor.authorVicedo-Cabrera, Ana Maria
dc.contributor.authorBell, Michelle L.
dc.contributor.authorLavigne, Eric
dc.contributor.authorKan, Haidong
dc.contributor.authorGasparrini, Antonio
dc.contributor.authorMCC Collaborative Research Network
dc.date.accessioned2023-10-09T11:11:10Z
dc.date.available2023-10-09T11:11:10Z
dc.date.issued2023-03-08
dc.descriptionThe Multi-City Multi-Country Collaborative Research Network group authorship includes G. Carrasco, B.-Y. Chen, A. Entezari, Y. Guo, Y.L. Guo, M. Hashizume, I.-H. Holobaca, C. Íñiguez, J.J.K. Jaakkola, H. Kim, W. Lee, S. Li, M. Maasikmets, F. Mayvaneh, *B. Nunes*, H. Orru, S. Osorio, M.S. Ragettli, N. Ryti, P.H.N. Saldiva, A. Schneider, J. Schwartz, S. Tong, and A. Zanobetti.pt_PT
dc.descriptionB. Nunes - Departamento de Epidemiologia do INSApt_PT
dc.description.abstractBackground: Epidemiological evidence on the health risks of sulfur dioxide (sulfur dioxide SO2) is more limited compared with other pollutants, and doubts remain on several aspects, such as the form of the exposure–response relationship, the potential role of copollutants, as well as the actual risk at low concentrations and possible temporal variation in risks. Objectives: Our aim was to assess the short-term association between exposure to sulfur dioxide SO2 and daily mortality in a large multilocation data set, using advanced study designs and statistical techniques. Methods: The analysis included 43,729,018 deaths that occurred in 399 cities within 23 countries between 1980 and 2018. A two-stage design was applied to assess the association between the daily concentration of sulfur dioxide SO2 and mortality counts, including first-stage time-series regressions and second-stage multilevel random-effect meta-analyses. Secondary analyses assessed the exposure–response shape and the lag structure using spline terms and distributed lag models, respectively, and temporal variations in risk using a longitudinal meta-regression. Bi-pollutant models were applied to examine confounding effects of particulate matter with an aerodynamic diameter of less than or equal to 10 micrometers≤10μm (particulate matter begin subscript 10 end subscriptPM10) and 2.5 micrometers2.5μm (particulate matter begin subscript 2.5 end subscriptPM2.5), ozone, nitrogen dioxide, and carbon monoxide. Associations were reported as relative risks (RRs) and fractions of excess deaths. Results: The average daily concentration of sulfur dioxideSO2 across the 399 cities was 11.7 micrograms per meter cubed11.7 μg/m3, with 4.7% of days above the World Health Organization (WHO) guideline limit (40 micrograms per meter cubed40 μg/m3, 24-h average), although the exceedances occurred predominantly in specific locations. Exposure levels decreased considerably during the study period, from an average concentration of 19.0 micrograms per meter cubed19.0 μg/m3 in 1980–1989 to 6.3 micrograms per meter cubed6.3 μg/m3 in 2010–2018. For all locations combined, a 10 microgram per meter cubed10-μg/m3 increase in daily sulfur dioxide SO2 was associated with an RR of mortality of 1.0045 [95% confidence interval (CI): 1.0019, 1.0070], with the risk being stable over time but with substantial between-country heterogeneity. Short-term exposure to sulfur dioxide SO2 was associated with an excess mortality fraction of 0.50% [95% empirical CI (eCI): 0.42%, 0.57%] in the 399 cities, although decreasing from 0.74% (0.61%, 0.85%) in 1980–1989 to 0.37% (0.27%, 0.47%) in 2010–2018. There was some evidence of nonlinearity, with a steep exposure–response relationship at low concentrations and the risk attenuating at higher levels. The relevant lag window was 0–3 d. Significant positive associations remained after controlling for other pollutants. Discussion: The analysis revealed independent mortality risks associated with short-term exposure to sulfur dioxideSO2, with no evidence of a threshold. Levels below the current WHO guidelines for 24-h averages were still associated with substantial excess mortality, indicating the potential benefits of stricter air quality standards.pt_PT
dc.description.sponsorshipThis study was supported by the Medical Research Council UK[MR/R013349/1 (to A.G.)] and the European Union’s Horizon 2020Project Exhaustion [820655 (to A.G.)]. Additional grants supportedindividual researchers: H.K. was supported by the National NaturalScience Foundation of China (92043301), J.M. was supported by afellowship of Fundação para a Ciência e a Tecnlogia (SFRH/BPD/115112/2016), and A.T. was supported by Ministerio de Ciencia eInnovacion/Agencia Estatal de Investigación (MCIN/AEI/10.13039/501100011033; CEX2018-000794-S).The Multi-City Multi-Country Collaborative Research Networkgroup authorship includes G. Carrasco, B.-Y. Chen, A. Entezari,Y. Guo, Y.L. Guo, M. Hashizume, I.-H. Holobaca, C. Íñiguez,J.J.K. Jaakkola, H. Kim, W. Lee, S. Li, M. Maasikmets,F. Mayvaneh, B. Nunes, H. Orru, S. Osorio, M.S. Ragettli, N. Ryti,P.H.N. Saldiva, A. Schneider, J. Schwartz, S. Tong, and A. Zanobettipt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEnviron Health Perspect. 2023 Mar;131(3):37002. doi: 10.1289/EHP11112. Epub 2023 Mar 8.pt_PT
dc.identifier.doi10.1289/EHP11112pt_PT
dc.identifier.issn0091-6765
dc.identifier.urihttp://hdl.handle.net/10400.18/8672
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Institute of Environmental Health Sciencespt_PT
dc.relationExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
dc.relationEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
dc.relation.publisherversionhttps://ehp.niehs.nih.gov/doi/10.1289/EHP11112pt_PT
dc.subjectMulti-Country Multi-Citypt_PT
dc.subjectSulfur Dioxidept_PT
dc.subjectSO2pt_PT
dc.subjectMortalitypt_PT
dc.subjectAir Pollutionpt_PT
dc.subjectEnvironmental Exposurept_PT
dc.subjectHumanspt_PT
dc.subjectEpidemiologypt_PT
dc.subjectEnvironmental Pollutantspt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleShort-Term Association between Sulfur Dioxide and Mortality: A Multicountry Analysis in 399 Citiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExposure to heat and air pollution in EUrope – cardiopulmonary impacts and benefits of mitigation and adaptation
oaire.awardTitleEarly life exposure to atmospheric air pollutants and potential DNA damage: Consequences on development and childhood outcomes APPEAL
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/820655/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F115112%2F2016/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage37002pt_PT
oaire.citation.titleEnvironmental Health Perspectivespt_PT
oaire.citation.volume131pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctAcesso de acordo com política editorial da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication59609b8b-2750-43e0-8fe9-155a4915a572
relation.isProjectOfPublication0c38fa63-8890-47d4-b3d3-1aa47f53b966
relation.isProjectOfPublication.latestForDiscovery59609b8b-2750-43e0-8fe9-155a4915a572

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2023_obrien_eph.pdf
Size:
1.55 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DEP - Artigos em revistas internacionais
DSA - Artigos em revistas internacionais